Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study
Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and Verbenaceae have been subjected to an interdisciplinary study since the seventies, when Dr. Benjamin Gilbert, at the Federal University of Rio de Janeiro, launched a program on the chemistry of natural products active a...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2001-01-01
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| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300003 |
| _version_ | 1828527910572523520 |
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| author | De Moura Kelly C. G. Emery Flávio S. Neves-Pinto Cleverson Pinto Maria do Carmo F. R. Dantas Andrea P. Salomão Kelly Castro Solange L. de Pinto Antônio V. |
| author_facet | De Moura Kelly C. G. Emery Flávio S. Neves-Pinto Cleverson Pinto Maria do Carmo F. R. Dantas Andrea P. Salomão Kelly Castro Solange L. de Pinto Antônio V. |
| author_sort | De Moura Kelly C. G. |
| collection | DOAJ |
| description | Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and Verbenaceae have been subjected to an interdisciplinary study since the seventies, when Dr. Benjamin Gilbert, at the Federal University of Rio de Janeiro, launched a program on the chemistry of natural products active against endemic diseases. In this paper we describe the synthesis of five naphthoimidazoles, derived from this program and their activity towards T. cruzi, the etiologic agent of Chagas disease. We also review the influence of chemical structure on trypanocidal action of naphthoquinones and of derived heterocycles with imidazole, oxazole, phenoxazine, indole, dipyrane and cyclopentene rings. The overall analysis corroborates the tendency of trypanocidal activity in compounds with an imidazole or oxazole ring linked to a naphthopyrane structure. Two naphthoimidazoles presented higher activities (14.5x and 34.8x) than the standard crystal violet. Emphasis is given to the biodiversity of the Brazilian flora as a starting point for the development of an autonomous and creative medicinal chemistry. |
| first_indexed | 2024-12-11T21:44:45Z |
| format | Article |
| id | doaj.art-b4d73be805314e27ad3e548d25d41c15 |
| institution | Directory Open Access Journal |
| issn | 0103-5053 |
| language | English |
| last_indexed | 2024-12-11T21:44:45Z |
| publishDate | 2001-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Journal of the Brazilian Chemical Society |
| spelling | doaj.art-b4d73be805314e27ad3e548d25d41c152022-12-22T00:49:41ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50532001-01-01123325338Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary studyDe Moura Kelly C. G.Emery Flávio S.Neves-Pinto CleversonPinto Maria do Carmo F. R.Dantas Andrea P.Salomão KellyCastro Solange L. dePinto Antônio V.Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and Verbenaceae have been subjected to an interdisciplinary study since the seventies, when Dr. Benjamin Gilbert, at the Federal University of Rio de Janeiro, launched a program on the chemistry of natural products active against endemic diseases. In this paper we describe the synthesis of five naphthoimidazoles, derived from this program and their activity towards T. cruzi, the etiologic agent of Chagas disease. We also review the influence of chemical structure on trypanocidal action of naphthoquinones and of derived heterocycles with imidazole, oxazole, phenoxazine, indole, dipyrane and cyclopentene rings. The overall analysis corroborates the tendency of trypanocidal activity in compounds with an imidazole or oxazole ring linked to a naphthopyrane structure. Two naphthoimidazoles presented higher activities (14.5x and 34.8x) than the standard crystal violet. Emphasis is given to the biodiversity of the Brazilian flora as a starting point for the development of an autonomous and creative medicinal chemistry.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300003naphthoquinonesheterocyclesTabebuiaTrypanosoma cruziChagas disease |
| spellingShingle | De Moura Kelly C. G. Emery Flávio S. Neves-Pinto Cleverson Pinto Maria do Carmo F. R. Dantas Andrea P. Salomão Kelly Castro Solange L. de Pinto Antônio V. Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study Journal of the Brazilian Chemical Society naphthoquinones heterocycles Tabebuia Trypanosoma cruzi Chagas disease |
| title | Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study |
| title_full | Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study |
| title_fullStr | Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study |
| title_full_unstemmed | Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study |
| title_short | Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study |
| title_sort | trypanocidal activity of isolated naphthoquinones from tabebuia and some heterocyclic derivatives a review from an interdisciplinary study |
| topic | naphthoquinones heterocycles Tabebuia Trypanosoma cruzi Chagas disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300003 |
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