Phosphazene-catalyzed desymmetrization of cyclohexadienones by dithiane addition

Phosphazene-catalyzed desymmetrization of cyclohexadienones by dithiane addition

We report a desymmetrization of cyclohexadienones by intramolecular conjugate addition of a tethered dithiane nucleophile. Mild reaction conditions allow the formation of diversely functionalized fused bicyclic lactones. The products participate in facially selective additions from the convex surfac...

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Bibliographic Details
Main Authors:	Matthew A. Horwitz, Elisabetta Massolo, Jeffrey S. Johnson
Format:	Article
Language:	English
Published:	Beilstein-Institut 2017-04-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	conjugate addition cyclohexadienones dearomatization desymmetrization dithiane iminophosphoranes organocatalysis phosphazenes
Online Access:	https://doi.org/10.3762/bjoc.13.75

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