Regulation of Aging and Longevity by Ion Channels and Transporters
Despite significant advances in our understanding of the mechanisms that underlie age-related physiological decline, our ability to translate these insights into actionable strategies to extend human healthspan has been limited. One of the major reasons for the existence of this barrier is that with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/7/1180 |
| _version_ | 1797439934187962368 |
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| author | Kartik Venkatachalam |
| author_facet | Kartik Venkatachalam |
| author_sort | Kartik Venkatachalam |
| collection | DOAJ |
| description | Despite significant advances in our understanding of the mechanisms that underlie age-related physiological decline, our ability to translate these insights into actionable strategies to extend human healthspan has been limited. One of the major reasons for the existence of this barrier is that with a few important exceptions, many of the proteins that mediate aging have proven to be undruggable. The argument put forth here is that the amenability of ion channels and transporters to pharmacological manipulation could be leveraged to develop novel therapeutic strategies to combat aging. This review delves into the established roles for ion channels and transporters in the regulation of aging and longevity via their influence on membrane excitability, Ca<sup>2+</sup> homeostasis, mitochondrial and endolysosomal function, and the transduction of sensory stimuli. The goal is to provide the reader with an understanding of emergent themes, and prompt further investigation into how the activities of ion channels and transporters sculpt the trajectories of cellular and organismal aging. |
| first_indexed | 2024-03-09T12:00:56Z |
| format | Article |
| id | doaj.art-b4d7f8ec677243d6a83c9e87699ab068 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T12:00:56Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b4d7f8ec677243d6a83c9e87699ab0682023-11-30T23:04:34ZengMDPI AGCells2073-44092022-03-01117118010.3390/cells11071180Regulation of Aging and Longevity by Ion Channels and TransportersKartik Venkatachalam0Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth-Houston), Houston, TX 77030, USADespite significant advances in our understanding of the mechanisms that underlie age-related physiological decline, our ability to translate these insights into actionable strategies to extend human healthspan has been limited. One of the major reasons for the existence of this barrier is that with a few important exceptions, many of the proteins that mediate aging have proven to be undruggable. The argument put forth here is that the amenability of ion channels and transporters to pharmacological manipulation could be leveraged to develop novel therapeutic strategies to combat aging. This review delves into the established roles for ion channels and transporters in the regulation of aging and longevity via their influence on membrane excitability, Ca<sup>2+</sup> homeostasis, mitochondrial and endolysosomal function, and the transduction of sensory stimuli. The goal is to provide the reader with an understanding of emergent themes, and prompt further investigation into how the activities of ion channels and transporters sculpt the trajectories of cellular and organismal aging.https://www.mdpi.com/2073-4409/11/7/1180longevityion channelslifespanagingcalciumER |
| spellingShingle | Kartik Venkatachalam Regulation of Aging and Longevity by Ion Channels and Transporters Cells longevity ion channels lifespan aging calcium ER |
| title | Regulation of Aging and Longevity by Ion Channels and Transporters |
| title_full | Regulation of Aging and Longevity by Ion Channels and Transporters |
| title_fullStr | Regulation of Aging and Longevity by Ion Channels and Transporters |
| title_full_unstemmed | Regulation of Aging and Longevity by Ion Channels and Transporters |
| title_short | Regulation of Aging and Longevity by Ion Channels and Transporters |
| title_sort | regulation of aging and longevity by ion channels and transporters |
| topic | longevity ion channels lifespan aging calcium ER |
| url | https://www.mdpi.com/2073-4409/11/7/1180 |
| work_keys_str_mv | AT kartikvenkatachalam regulationofagingandlongevitybyionchannelsandtransporters |