Colorectal cancer‐initiating cells caught in the act
Abstract Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic approaches for cancer. Tumor‐initiating cells (TIC) (a.k.a. cancer stem cells) are on the apex in this hierarchy and can self‐renew...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2017-05-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.201707858 |
| _version_ | 1827059849228189696 |
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| author | Sebastian M Dieter Hanno Glimm Claudia R Ball |
| author_facet | Sebastian M Dieter Hanno Glimm Claudia R Ball |
| author_sort | Sebastian M Dieter |
| collection | DOAJ |
| description | Abstract Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic approaches for cancer. Tumor‐initiating cells (TIC) (a.k.a. cancer stem cells) are on the apex in this hierarchy and can self‐renew and differentiate, thereby continuously fueling tumor growth and metastasis formation. This process was previously thought to be unidirectional. Self‐renewing TIC therefore represent highly attractive targets for therapeutic intervention. |
| first_indexed | 2024-03-07T16:41:35Z |
| format | Article |
| id | doaj.art-b4d8be118cce48e187cdd3b6d3dc4afa |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2025-02-18T18:48:04Z |
| publishDate | 2017-05-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-b4d8be118cce48e187cdd3b6d3dc4afa2024-10-20T11:36:51ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842017-05-019785685810.15252/emmm.201707858Colorectal cancer‐initiating cells caught in the actSebastian M Dieter0Hanno Glimm1Claudia R Ball2Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)Abstract Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic approaches for cancer. Tumor‐initiating cells (TIC) (a.k.a. cancer stem cells) are on the apex in this hierarchy and can self‐renew and differentiate, thereby continuously fueling tumor growth and metastasis formation. This process was previously thought to be unidirectional. Self‐renewing TIC therefore represent highly attractive targets for therapeutic intervention.https://doi.org/10.15252/emmm.201707858 |
| spellingShingle | Sebastian M Dieter Hanno Glimm Claudia R Ball Colorectal cancer‐initiating cells caught in the act EMBO Molecular Medicine |
| title | Colorectal cancer‐initiating cells caught in the act |
| title_full | Colorectal cancer‐initiating cells caught in the act |
| title_fullStr | Colorectal cancer‐initiating cells caught in the act |
| title_full_unstemmed | Colorectal cancer‐initiating cells caught in the act |
| title_short | Colorectal cancer‐initiating cells caught in the act |
| title_sort | colorectal cancer initiating cells caught in the act |
| url | https://doi.org/10.15252/emmm.201707858 |
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