A Case of Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm Composed With Adenoma and Neuroendocrine Tumor
Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) of the gastrointestinal tract, particularly gastric MiNENs are rare, and a gastric adenoma that occurs concomitant with a neuroendocrine carcinoma (and not gastric adenocarcinoma) is extremely rare. The clinicopathologic and pathogenetic feat...
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| Format: | Article |
| Language: | English |
| Published: |
Yong Chan Lee
2023-12-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://helicojournal.org/upload/pdf/kjhugr-2023-0038.pdf |
| _version_ | 1797387688615084032 |
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| author | Kwon-Eui Hong Yeon Ji Kim Yoon Jung Choi |
| author_facet | Kwon-Eui Hong Yeon Ji Kim Yoon Jung Choi |
| author_sort | Kwon-Eui Hong |
| collection | DOAJ |
| description | Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) of the gastrointestinal tract, particularly gastric MiNENs are rare, and a gastric adenoma that occurs concomitant with a neuroendocrine carcinoma (and not gastric adenocarcinoma) is extremely rare. The clinicopathologic and pathogenetic features of MiNENs remain unclear, and treatment guidelines are currently unavailable. A 75-year-old man patient was referred to our hospital for management of a gastric adenoma. Endoscopy revealed an elevated mucosal lesion (10 mm×10 mm) at the greater curvature of the lower gastric body. The patient underwent endoscopic submucosal dissection for removal of the gastric neoplasm. Histopathological evaluation revealed mixed epithelial dysplasia, low and partly high grade and a neuroendocrine tumor (grade 1). Immunohistochemical analysis showed neoplastic cells with immunopositivity for CD56, synaptophysin, and INSM1, and Ki-67 showed 2.2%. Therefore, the patient was diagnosed with a low-grade gastric MiNEN. We present a rare case of gastric MiNENs (adenoma-neuroendocrine tumor) together with a literature review. |
| first_indexed | 2024-03-08T22:29:41Z |
| format | Article |
| id | doaj.art-b4da84cb3657420896d226c715754370 |
| institution | Directory Open Access Journal |
| issn | 1738-3331 |
| language | English |
| last_indexed | 2024-03-08T22:29:41Z |
| publishDate | 2023-12-01 |
| publisher | Yong Chan Lee |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj.art-b4da84cb3657420896d226c7157543702023-12-18T07:11:45ZengYong Chan LeeThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312023-12-0123430230510.7704/kjhugr.2023.0038808A Case of Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm Composed With Adenoma and Neuroendocrine TumorKwon-Eui Hong0Yeon Ji Kim1Yoon Jung Choi2 Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea Departments of Pathology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, KoreaMixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) of the gastrointestinal tract, particularly gastric MiNENs are rare, and a gastric adenoma that occurs concomitant with a neuroendocrine carcinoma (and not gastric adenocarcinoma) is extremely rare. The clinicopathologic and pathogenetic features of MiNENs remain unclear, and treatment guidelines are currently unavailable. A 75-year-old man patient was referred to our hospital for management of a gastric adenoma. Endoscopy revealed an elevated mucosal lesion (10 mm×10 mm) at the greater curvature of the lower gastric body. The patient underwent endoscopic submucosal dissection for removal of the gastric neoplasm. Histopathological evaluation revealed mixed epithelial dysplasia, low and partly high grade and a neuroendocrine tumor (grade 1). Immunohistochemical analysis showed neoplastic cells with immunopositivity for CD56, synaptophysin, and INSM1, and Ki-67 showed 2.2%. Therefore, the patient was diagnosed with a low-grade gastric MiNEN. We present a rare case of gastric MiNENs (adenoma-neuroendocrine tumor) together with a literature review.http://helicojournal.org/upload/pdf/kjhugr-2023-0038.pdfneoplasmsneuroendocrine tumorsstomach neoplasms |
| spellingShingle | Kwon-Eui Hong Yeon Ji Kim Yoon Jung Choi A Case of Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm Composed With Adenoma and Neuroendocrine Tumor The Korean Journal of Helicobacter and Upper Gastrointestinal Research neoplasms neuroendocrine tumors stomach neoplasms |
| title | A Case of Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm Composed With Adenoma and Neuroendocrine Tumor |
| title_full | A Case of Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm Composed With Adenoma and Neuroendocrine Tumor |
| title_fullStr | A Case of Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm Composed With Adenoma and Neuroendocrine Tumor |
| title_full_unstemmed | A Case of Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm Composed With Adenoma and Neuroendocrine Tumor |
| title_short | A Case of Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm Composed With Adenoma and Neuroendocrine Tumor |
| title_sort | case of gastric mixed neuroendocrine nonneuroendocrine neoplasm composed with adenoma and neuroendocrine tumor |
| topic | neoplasms neuroendocrine tumors stomach neoplasms |
| url | http://helicojournal.org/upload/pdf/kjhugr-2023-0038.pdf |
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