Lgr5+CD44+EpCAM+ Strictly Defines Cancer Stem Cells in Human Colorectal Cancer

Lgr5+CD44+EpCAM+ Strictly Defines Cancer Stem Cells in Human Colorectal Cancer

Background/Aims: Although EpCAM+CD44+ cells exhibit more stem-like properties than did EpCAM-CD44- cells, the specificity of EpCAM combined with CD44 in defining CSCs needs further improvement. Lgr5 is used as a biomarker to isolate cancer stem cells (CSCs) in colorectal cancer. However, it remains...

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Bibliographic Details
Main Authors: Zhengwei Leng, Qinghua Xia, Jinhuang Chen, Yong Li, Jiqian Xu, Ende Zhao, Hai Zheng, Walden Ai, Jiangchuan Dong
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Lgr5
CD44
EpCAM
Colorectal cancer
Cancer stem cells
Biomarkers
Epithelial-mesenchymal transition
Online Access:https://www.karger.com/Article/FullText/488743

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