Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury

Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury

Abstract Background Human mesenchymal stromal cell (MSC)-derived extracellular vesicles (EV) revealed neuroprotective potentials in various brain injury models, including neonatal encephalopathy caused by hypoxia–ischemia (HI). However, for clinical translation of an MSC-EV therapy, scaled manufactu...

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Bibliographic Details
Main Authors: Nicole Labusek, Yanis Mouloud, Christian Köster, Eva Diesterbeck, Tobias Tertel, Constanze Wiek, Helmut Hanenberg, Peter A. Horn, Ursula Felderhoff-Müser, Ivo Bendix, Bernd Giebel, Josephine Herz
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Inflammation and Regeneration
Subjects:
Neonatal encephalopathy
Hypoxia–ischemia
Neuroinflammation
Neuroregeneration
Mesenchymal stromal cells
Extracellular vesicles
Online Access:https://doi.org/10.1186/s41232-023-00274-6

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