Prevalence of Haemoglobinopathies in Children Presenting with Anemia at DHQ Hospital Zhob, Balochistan
OBJECTIVE: To find the prevalence of haemoglobinopathies in children presenting with anemia at District Headquarter Hospital Zhob. METHODOLOGY: The cross-sectional study was carried out at District Headquarter Hospital (DHQ) Zhob from March to August 2021. Patients aged 6 months to 15 years present...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Liaquat University of Medical and Health Sciences
2021-12-01
|
| Series: | JLUMHS |
| Subjects: | |
| Online Access: | https://www.lumhs.edu.pk/jlumhs/Vol20No05/06.pdf |
| _version_ | 1827949537428242432 |
|---|---|
| author | Sumera Akram Saeed Akhtar Khan Khattak Muhammad Ahmed Khan Syed Asad Ali Muhammad Ameen Khan |
| author_facet | Sumera Akram Saeed Akhtar Khan Khattak Muhammad Ahmed Khan Syed Asad Ali Muhammad Ameen Khan |
| author_sort | Sumera Akram |
| collection | DOAJ |
| description | OBJECTIVE: To find the prevalence of haemoglobinopathies in children presenting with anemia at District Headquarter Hospital Zhob.
METHODOLOGY: The cross-sectional study was carried out at District Headquarter Hospital (DHQ) Zhob from March to August 2021. Patients aged 6 months to 15 years presented with signs and symptoms of anemia were included in the study and investigated for haemoglobinopathies through complete blood count, peripheral smear, iron studies (serum ferritin), haemoglobin analysis by haemoglobinelectrophoresis, high-performance liquid chromatography and sickling test. All the data, including age, gender, and diseases was recorded and analyzed with the help of a statistical package for social sciences (SPSS 21).
RESULTS: A total of 2258 children were clinically suspected of anemia and were advised the sequential blood tests for diagnosing Haemoglobinopathies. Out of these, 239 cases lost to follow up. The remaining 2019 caseswere included, comprising1026 males (50.81%) and 993 females (49.18%) with a mean age 8.09±3.78 years. Haemoglobinopathies constituted 8.9%ofpediatric diseases and 56.7% of anemia cases. The most common haemoglobinopathy was beta-thalassemia major (29.4%), followed by sickle / beta-thalassemia compound heterozygous (28.3%), sickle cell disease (28%), HbH“alpha thalassemia” (2.8%), HbD trait (2.3%), HbE/Beta-thalassemia (2%), HbD Homozygous (1.8%), HbD/beta thalassemia (1.5%), HbE trait (1.1%)and Beta-thalassemia minor (0.9%). There were 11 cases (1%) reports labeled as borderline.
CONCLUSION: Haemoglobinopathies constitute a major portion of diseases and the most common cause of anemia in the pediatric population of Zhob. |
| first_indexed | 2024-04-09T13:11:35Z |
| format | Article |
| id | doaj.art-b4de0211395140db8f8f35e5eba1fbc3 |
| institution | Directory Open Access Journal |
| issn | 1729-0341 2309-8627 |
| language | English |
| last_indexed | 2024-04-09T13:11:35Z |
| publishDate | 2021-12-01 |
| publisher | Liaquat University of Medical and Health Sciences |
| record_format | Article |
| series | JLUMHS |
| spelling | doaj.art-b4de0211395140db8f8f35e5eba1fbc32023-05-12T06:52:58ZengLiaquat University of Medical and Health SciencesJLUMHS1729-03412309-86272021-12-012005314318doi:10.22442/jlumhs.2021.00904Prevalence of Haemoglobinopathies in Children Presenting with Anemia at DHQ Hospital Zhob, BalochistanSumera Akram0Saeed Akhtar Khan Khattak1Muhammad Ahmed Khan2Syed Asad Ali3Muhammad Ameen Khan4DHQ Hospital Zhob, Balochistan-PakistanCMH Mardan, KPK-PakistanCMH Zhob, Balochistan-PakistanCMH Zhob, Balochistan-PakistanCMH Mardan, KPK-PakistanOBJECTIVE: To find the prevalence of haemoglobinopathies in children presenting with anemia at District Headquarter Hospital Zhob. METHODOLOGY: The cross-sectional study was carried out at District Headquarter Hospital (DHQ) Zhob from March to August 2021. Patients aged 6 months to 15 years presented with signs and symptoms of anemia were included in the study and investigated for haemoglobinopathies through complete blood count, peripheral smear, iron studies (serum ferritin), haemoglobin analysis by haemoglobinelectrophoresis, high-performance liquid chromatography and sickling test. All the data, including age, gender, and diseases was recorded and analyzed with the help of a statistical package for social sciences (SPSS 21). RESULTS: A total of 2258 children were clinically suspected of anemia and were advised the sequential blood tests for diagnosing Haemoglobinopathies. Out of these, 239 cases lost to follow up. The remaining 2019 caseswere included, comprising1026 males (50.81%) and 993 females (49.18%) with a mean age 8.09±3.78 years. Haemoglobinopathies constituted 8.9%ofpediatric diseases and 56.7% of anemia cases. The most common haemoglobinopathy was beta-thalassemia major (29.4%), followed by sickle / beta-thalassemia compound heterozygous (28.3%), sickle cell disease (28%), HbH“alpha thalassemia” (2.8%), HbD trait (2.3%), HbE/Beta-thalassemia (2%), HbD Homozygous (1.8%), HbD/beta thalassemia (1.5%), HbE trait (1.1%)and Beta-thalassemia minor (0.9%). There were 11 cases (1%) reports labeled as borderline. CONCLUSION: Haemoglobinopathies constitute a major portion of diseases and the most common cause of anemia in the pediatric population of Zhob. https://www.lumhs.edu.pk/jlumhs/Vol20No05/06.pdfhaemoglobinopathyanemiathalassemiavitamin b12folateiron deficiency anemia |
| spellingShingle | Sumera Akram Saeed Akhtar Khan Khattak Muhammad Ahmed Khan Syed Asad Ali Muhammad Ameen Khan Prevalence of Haemoglobinopathies in Children Presenting with Anemia at DHQ Hospital Zhob, Balochistan JLUMHS haemoglobinopathy anemia thalassemia vitamin b12 folate iron deficiency anemia |
| title | Prevalence of Haemoglobinopathies in Children Presenting with Anemia at DHQ Hospital Zhob, Balochistan |
| title_full | Prevalence of Haemoglobinopathies in Children Presenting with Anemia at DHQ Hospital Zhob, Balochistan |
| title_fullStr | Prevalence of Haemoglobinopathies in Children Presenting with Anemia at DHQ Hospital Zhob, Balochistan |
| title_full_unstemmed | Prevalence of Haemoglobinopathies in Children Presenting with Anemia at DHQ Hospital Zhob, Balochistan |
| title_short | Prevalence of Haemoglobinopathies in Children Presenting with Anemia at DHQ Hospital Zhob, Balochistan |
| title_sort | prevalence of haemoglobinopathies in children presenting with anemia at dhq hospital zhob balochistan |
| topic | haemoglobinopathy anemia thalassemia vitamin b12 folate iron deficiency anemia |
| url | https://www.lumhs.edu.pk/jlumhs/Vol20No05/06.pdf |
| work_keys_str_mv | AT sumeraakram prevalenceofhaemoglobinopathiesinchildrenpresentingwithanemiaatdhqhospitalzhobbalochistan AT saeedakhtarkhankhattak prevalenceofhaemoglobinopathiesinchildrenpresentingwithanemiaatdhqhospitalzhobbalochistan AT muhammadahmedkhan prevalenceofhaemoglobinopathiesinchildrenpresentingwithanemiaatdhqhospitalzhobbalochistan AT syedasadali prevalenceofhaemoglobinopathiesinchildrenpresentingwithanemiaatdhqhospitalzhobbalochistan AT muhammadameenkhan prevalenceofhaemoglobinopathiesinchildrenpresentingwithanemiaatdhqhospitalzhobbalochistan |