Maternal Smoking During Pregnancy Induces Persistent Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic Risk

Maternal Smoking During Pregnancy Induces Persistent Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic Risk

Background: Several studies have shown effects of current and maternal smoking during pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we hypothesized that there are long-term and persistent epigenetic effects following maternal smoking during pregnancy on adolescent of...

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Bibliographic Details
Main Authors: Sebastian Rauschert, Phillip E. Melton, Graham Burdge, Jeffrey M. Craig, Keith M. Godfrey, Joanna D. Holbrook, Karen Lillycrop, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy, Craig Pennell, Rae-Chi Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Genetics
Subjects:
DNA methylation
maternal smoking during pregnancy
epigenetics
Raine Study
cardiometabolic health
adolescence
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00770/full

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