Epi-Mucosa Fixation and Autologous Platelet-Rich Fibrin Treatment in Medication-Related Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MRONJ) frequently affects patients after treatments with bisphosphonates or denosumab, especially with high doses in patients with bone osteoporosis, neoplastic metastases, or possibly anti-angiogenic treatment for cancer. The aim of this article was to s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/9/5/50 |
| _version_ | 1827693653144895488 |
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| author | Antonio Cortese Antonio Casarella Candace M. Howard Pier Paolo Claudio |
| author_facet | Antonio Cortese Antonio Casarella Candace M. Howard Pier Paolo Claudio |
| author_sort | Antonio Cortese |
| collection | DOAJ |
| description | Medication-related osteonecrosis of the jaw (MRONJ) frequently affects patients after treatments with bisphosphonates or denosumab, especially with high doses in patients with bone osteoporosis, neoplastic metastases, or possibly anti-angiogenic treatment for cancer. The aim of this article was to show a new treatment planning for stage 2 and stage 3 MRONJ using platelet-rich fibrin (PRF) at the surgical field to enhance healing in association with a new epi-mucosal fixation technique to prevent or treat mandibular fracture. Two cases were treated by epi-mucosa fixation and autologous PRF use for prevention of mandibular fracture risks related to necrotic bone resection or a narrow fracture reduction. Both cases were successfully treated by this new technique of epi-mucosa fixation combined with autologous PRF and achieved good results and good quality of life. Ability to wear prosthesis with good mastication in the absence of side effect such as infection, plate and screw mobilization, pain, and other disabilities or extension of necrosis was reported. After surgical removal of necrotic bone, no infection was detected without any extension of the necrosis. |
| first_indexed | 2024-03-10T11:48:27Z |
| format | Article |
| id | doaj.art-b4df96806d264c38af404142deb9398e |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-10T11:48:27Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-b4df96806d264c38af404142deb9398e2023-11-21T17:54:19ZengMDPI AGDentistry Journal2304-67672021-04-01955010.3390/dj9050050Epi-Mucosa Fixation and Autologous Platelet-Rich Fibrin Treatment in Medication-Related Osteonecrosis of the JawAntonio Cortese0Antonio Casarella1Candace M. Howard2Pier Paolo Claudio3Unit of Maxillofacial Surgery, Department of Medicine and Surgery, University of Salerno, 84084 Fisciano, ItalyUnit of Maxillofacial Surgery, Department of Medicine and Surgery, University of Salerno, 84084 Fisciano, ItalyDepartment of Radiology, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Biomolecular Sciences, Maxillofacial Surgery, University of Mississippi, Jackson, MS 39216, USAMedication-related osteonecrosis of the jaw (MRONJ) frequently affects patients after treatments with bisphosphonates or denosumab, especially with high doses in patients with bone osteoporosis, neoplastic metastases, or possibly anti-angiogenic treatment for cancer. The aim of this article was to show a new treatment planning for stage 2 and stage 3 MRONJ using platelet-rich fibrin (PRF) at the surgical field to enhance healing in association with a new epi-mucosal fixation technique to prevent or treat mandibular fracture. Two cases were treated by epi-mucosa fixation and autologous PRF use for prevention of mandibular fracture risks related to necrotic bone resection or a narrow fracture reduction. Both cases were successfully treated by this new technique of epi-mucosa fixation combined with autologous PRF and achieved good results and good quality of life. Ability to wear prosthesis with good mastication in the absence of side effect such as infection, plate and screw mobilization, pain, and other disabilities or extension of necrosis was reported. After surgical removal of necrotic bone, no infection was detected without any extension of the necrosis.https://www.mdpi.com/2304-6767/9/5/50medication-related osteonecrosis of the jawfracturemandibleosteonecrosisbisphosphonates |
| spellingShingle | Antonio Cortese Antonio Casarella Candace M. Howard Pier Paolo Claudio Epi-Mucosa Fixation and Autologous Platelet-Rich Fibrin Treatment in Medication-Related Osteonecrosis of the Jaw Dentistry Journal medication-related osteonecrosis of the jaw fracture mandible osteonecrosis bisphosphonates |
| title | Epi-Mucosa Fixation and Autologous Platelet-Rich Fibrin Treatment in Medication-Related Osteonecrosis of the Jaw |
| title_full | Epi-Mucosa Fixation and Autologous Platelet-Rich Fibrin Treatment in Medication-Related Osteonecrosis of the Jaw |
| title_fullStr | Epi-Mucosa Fixation and Autologous Platelet-Rich Fibrin Treatment in Medication-Related Osteonecrosis of the Jaw |
| title_full_unstemmed | Epi-Mucosa Fixation and Autologous Platelet-Rich Fibrin Treatment in Medication-Related Osteonecrosis of the Jaw |
| title_short | Epi-Mucosa Fixation and Autologous Platelet-Rich Fibrin Treatment in Medication-Related Osteonecrosis of the Jaw |
| title_sort | epi mucosa fixation and autologous platelet rich fibrin treatment in medication related osteonecrosis of the jaw |
| topic | medication-related osteonecrosis of the jaw fracture mandible osteonecrosis bisphosphonates |
| url | https://www.mdpi.com/2304-6767/9/5/50 |
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