Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents
We recently reported that bacteria can be found within pancreatic ductal adenocarcinoma (PDAC) tumors. Some of these bacteria can metabolize and thereby inactivate the nucleoside analog gemcitabine. We demonstrated that the long isoform of the bacterial enzyme cytidine deaminase (CDD) mediates the m...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
|
| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1405139 |
| _version_ | 1797677163692949504 |
|---|---|
| author | Leore T. Geller Ravid Straussman |
| author_facet | Leore T. Geller Ravid Straussman |
| author_sort | Leore T. Geller |
| collection | DOAJ |
| description | We recently reported that bacteria can be found within pancreatic ductal adenocarcinoma (PDAC) tumors. Some of these bacteria can metabolize and thereby inactivate the nucleoside analog gemcitabine. We demonstrated that the long isoform of the bacterial enzyme cytidine deaminase (CDD) mediates the metabolism of gemcitabine. The clinical effect of overcoming this potential mechanism of drug resistance has yet to be studied. |
| first_indexed | 2024-03-11T22:41:05Z |
| format | Article |
| id | doaj.art-b4e0539c7058461b81a7b9be74fcd746 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:05Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-b4e0539c7058461b81a7b9be74fcd7462023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-01-015110.1080/23723556.2017.14051391405139Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agentsLeore T. Geller0Ravid Straussman1Weizmann Institute of ScienceWeizmann Institute of ScienceWe recently reported that bacteria can be found within pancreatic ductal adenocarcinoma (PDAC) tumors. Some of these bacteria can metabolize and thereby inactivate the nucleoside analog gemcitabine. We demonstrated that the long isoform of the bacterial enzyme cytidine deaminase (CDD) mediates the metabolism of gemcitabine. The clinical effect of overcoming this potential mechanism of drug resistance has yet to be studied.http://dx.doi.org/10.1080/23723556.2017.1405139chemoresistancedrug metabolismgemcitabinemycoplasmanovel therapeutic targetspancreatic ductal adenocarcinomapdacmechanisms of resistance to therapytumor microbiome |
| spellingShingle | Leore T. Geller Ravid Straussman Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents Molecular & Cellular Oncology chemoresistance drug metabolism gemcitabine mycoplasma novel therapeutic targets pancreatic ductal adenocarcinoma pdac mechanisms of resistance to therapy tumor microbiome |
| title | Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents |
| title_full | Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents |
| title_fullStr | Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents |
| title_full_unstemmed | Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents |
| title_short | Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents |
| title_sort | intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents |
| topic | chemoresistance drug metabolism gemcitabine mycoplasma novel therapeutic targets pancreatic ductal adenocarcinoma pdac mechanisms of resistance to therapy tumor microbiome |
| url | http://dx.doi.org/10.1080/23723556.2017.1405139 |
| work_keys_str_mv | AT leoretgeller intratumoralbacteriamayelicitchemoresistancebymetabolizinganticanceragents AT ravidstraussman intratumoralbacteriamayelicitchemoresistancebymetabolizinganticanceragents |