Isotopic Radiolabeling of the Antiretroviral Drug [<sup>18</sup>F]Dolutegravir for Pharmacokinetic PET Imaging

Isotopic Radiolabeling of the Antiretroviral Drug [<sup>18</sup>F]Dolutegravir for Pharmacokinetic PET Imaging

Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is one of the preferred therapeutic options to treat...

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Bibliographic Details
Main Authors: Marion Tisseraud, Sébastien Goutal, Thomas Bonasera, Maud Goislard, Delphine Desjardins, Roger Le Grand, Chris M. Parry, Nicolas Tournier, Bertrand Kuhnast, Fabien Caillé
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceuticals
Subjects:
fluorine-18
radiolabeling
dolutegravir
PET imaging
Online Access:https://www.mdpi.com/1424-8247/15/5/587

Internet

https://www.mdpi.com/1424-8247/15/5/587

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