Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension
OBJECTIVE: To analyze variations in leukocyte count and thromboxane B2 production in the femoral vein of patients with chronic venous hypertension (CVH). DESIGN: Prospective clinical study, controlled, non randomized and open. LOCATION: Hospital das Clínicas, Faculdade de Medicina da Universidade de...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801998000300006&lng=en&tlng=en |
| _version_ | 1818160979915046912 |
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| author | Paulo Celso Motta Guimarães Pedro Puech-Leão Baptista Muraco Netto Nelson Wolosker Ricardo Aun Lídia Uraco Yamamoto |
| author_facet | Paulo Celso Motta Guimarães Pedro Puech-Leão Baptista Muraco Netto Nelson Wolosker Ricardo Aun Lídia Uraco Yamamoto |
| author_sort | Paulo Celso Motta Guimarães |
| collection | DOAJ |
| description | OBJECTIVE: To analyze variations in leukocyte count and thromboxane B2 production in the femoral vein of patients with chronic venous hypertension (CVH). DESIGN: Prospective clinical study, controlled, non randomized and open. LOCATION: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, referral center, university hospital. PARTICIPANTS: 15 patients with recurring stasis ulcer were analyzed, selected randomly from the venous diseases outpatient center, and 4 without lower limb venous alterations were also analyzed. INTERVENTION: Blood samples from the femoral and brachial veins were drawn following supine and 45º reverse Trendelenburg. MAIN OUTCOMES MEASURES: Direct leukocyte count and analysis of the thomboxane B2 with enzyme linked immunosorbent assay test. RESULTS: After 30 minutes in reverse Trendelenburg, patients with CVH showed a leukocyte count reduced by ±27% (p=0.02) and thromboxane B2 levels increased by ±158% (p=0.02). CONCLUSIONS: We suggest that future studies of medications for stasis ulcers include their effects on leukocyte entrapment and thromboxane B2 production in the lower limb venous system. |
| first_indexed | 2024-12-11T16:10:29Z |
| format | Article |
| id | doaj.art-b4e1fbe551d9487b8ca0ef43728abe28 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-11T16:10:29Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-b4e1fbe551d9487b8ca0ef43728abe282022-12-22T00:59:05ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-946011631721172610.1590/S1516-31801998000300006S1516-31801998000300006Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertensionPaulo Celso Motta Guimarães0Pedro Puech-Leão1Baptista Muraco Netto2Nelson Wolosker3Ricardo Aun4Lídia Uraco Yamamoto5Universidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloOBJECTIVE: To analyze variations in leukocyte count and thromboxane B2 production in the femoral vein of patients with chronic venous hypertension (CVH). DESIGN: Prospective clinical study, controlled, non randomized and open. LOCATION: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, referral center, university hospital. PARTICIPANTS: 15 patients with recurring stasis ulcer were analyzed, selected randomly from the venous diseases outpatient center, and 4 without lower limb venous alterations were also analyzed. INTERVENTION: Blood samples from the femoral and brachial veins were drawn following supine and 45º reverse Trendelenburg. MAIN OUTCOMES MEASURES: Direct leukocyte count and analysis of the thomboxane B2 with enzyme linked immunosorbent assay test. RESULTS: After 30 minutes in reverse Trendelenburg, patients with CVH showed a leukocyte count reduced by ±27% (p=0.02) and thromboxane B2 levels increased by ±158% (p=0.02). CONCLUSIONS: We suggest that future studies of medications for stasis ulcers include their effects on leukocyte entrapment and thromboxane B2 production in the lower limb venous system.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801998000300006&lng=en&tlng=enVenous ulcersVenous insufficiencyWhite blood countThromboxane B2 |
| spellingShingle | Paulo Celso Motta Guimarães Pedro Puech-Leão Baptista Muraco Netto Nelson Wolosker Ricardo Aun Lídia Uraco Yamamoto Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension São Paulo Medical Journal Venous ulcers Venous insufficiency White blood count Thromboxane B2 |
| title | Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension |
| title_full | Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension |
| title_fullStr | Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension |
| title_full_unstemmed | Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension |
| title_short | Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension |
| title_sort | variations in white blood count thromboxane b2 levels and hematocrit in chronic venous hypertension |
| topic | Venous ulcers Venous insufficiency White blood count Thromboxane B2 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801998000300006&lng=en&tlng=en |
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