Wobble uridine tRNA modification: a new vulnerability of refractory melanoma
The enzymes catalysing the modification of the wobble uridine (U34) of tRNAs (U34-enzymes) play an important role in tumor development. We have recently demonstrated that the U34-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mRNA tra...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1513725 |
| _version_ | 1827809362925584384 |
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| author | Francesca Rapino Pierre Close |
| author_facet | Francesca Rapino Pierre Close |
| author_sort | Francesca Rapino |
| collection | DOAJ |
| description | The enzymes catalysing the modification of the wobble uridine (U34) of tRNAs (U34-enzymes) play an important role in tumor development. We have recently demonstrated that the U34-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mRNA translation. Moreover, depletion of U34-enzymes resensitizes resistant melanoma to targeted therapy. These results indicate that targeting U34-enzymes represents a new therapeutic opportunity for melanoma patients. |
| first_indexed | 2024-03-11T22:41:05Z |
| format | Article |
| id | doaj.art-b4e325e6e4c4473fb1d239ac09b26ff8 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:05Z |
| publishDate | 2018-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-b4e325e6e4c4473fb1d239ac09b26ff82023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-11-015610.1080/23723556.2018.15137251513725Wobble uridine tRNA modification: a new vulnerability of refractory melanomaFrancesca Rapino0Pierre Close1University of LiègeUniversity of LiègeThe enzymes catalysing the modification of the wobble uridine (U34) of tRNAs (U34-enzymes) play an important role in tumor development. We have recently demonstrated that the U34-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mRNA translation. Moreover, depletion of U34-enzymes resensitizes resistant melanoma to targeted therapy. These results indicate that targeting U34-enzymes represents a new therapeutic opportunity for melanoma patients.http://dx.doi.org/10.1080/23723556.2018.1513725wobble trna modificationmrna translationhif1αmelanomatargeted therapy |
| spellingShingle | Francesca Rapino Pierre Close Wobble uridine tRNA modification: a new vulnerability of refractory melanoma Molecular & Cellular Oncology wobble trna modification mrna translation hif1α melanoma targeted therapy |
| title | Wobble uridine tRNA modification: a new vulnerability of refractory melanoma |
| title_full | Wobble uridine tRNA modification: a new vulnerability of refractory melanoma |
| title_fullStr | Wobble uridine tRNA modification: a new vulnerability of refractory melanoma |
| title_full_unstemmed | Wobble uridine tRNA modification: a new vulnerability of refractory melanoma |
| title_short | Wobble uridine tRNA modification: a new vulnerability of refractory melanoma |
| title_sort | wobble uridine trna modification a new vulnerability of refractory melanoma |
| topic | wobble trna modification mrna translation hif1α melanoma targeted therapy |
| url | http://dx.doi.org/10.1080/23723556.2018.1513725 |
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