Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

Abstract Background The medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is characterized by non-healing exposed bone in the maxillofacial region. The pathogenesis of MRONJ (BP) is not fully understood. Giant, hypernucleated, inactive osteoclasts were foun...

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Bibliographic Details
Main Authors: Christian Gross, Manuel Weber, Kay Creutzburg, Patrick Möbius, Raimund Preidl, Kerstin Amann, Falk Wehrhan
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Translational Medicine
Subjects:
Bisphosphonate
Osteonecrosis
Osteomyelitis
Osteoradionecrosis
Osteoclasts
TRAP
Online Access:http://link.springer.com/article/10.1186/s12967-017-1230-8

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