Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing
PURPOSECancer genetic testing (CGT), a pathway to personalized medicine, is also being embraced in Nigeria. However, little is known about the influence of demographics and perceptions on individuals' willingness to access and pay for CGT. This study assessed patients' willingness to under...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2023-02-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO.21.00140 |
| _version_ | 1811162905805062144 |
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| author | Prisca O. Adejumo Toyin I.G. Aniagwu Olutosin A. Awolude Babatunde Adedokun Makayla Kochheiser Anthonia Sowunmi Abiodun Popoola Oladosu Ojengbede Dezheng Huo Olufunmilayo I. Olopade |
| author_facet | Prisca O. Adejumo Toyin I.G. Aniagwu Olutosin A. Awolude Babatunde Adedokun Makayla Kochheiser Anthonia Sowunmi Abiodun Popoola Oladosu Ojengbede Dezheng Huo Olufunmilayo I. Olopade |
| author_sort | Prisca O. Adejumo |
| collection | DOAJ |
| description | PURPOSECancer genetic testing (CGT), a pathway to personalized medicine, is also being embraced in Nigeria. However, little is known about the influence of demographics and perceptions on individuals' willingness to access and pay for CGT. This study assessed patients' willingness to undergo CGT in southwest Nigeria as a catalyst for sustainable Cancer Risk Management Program.METHODSThis was a cross-sectional study using semistructured questionnaire to interview 362 patients with cancer and 10 referred first-degree relatives between July 2018 and February 2020. Participants from three Nigerian teaching hospitals—University College Hospital, Ibadan, Lagos State University Teaching Hospital, Lagos, and Lagos University Teaching Hospital, Lagos, received genetic counseling and had subsequent CGT. Primary outcomes were willingness to undergo CGT in determining cancer risk and the willingness to pay for it. Ethical approval was from appropriate ethics committees of participating hospitals. Data were analyzed with SPSS version 22. Univariate comparison of categorical variables was performed by χ2 test, multivariate analysis by logistic regression.RESULTSThe participants from University College Hospital (56.2%), Lagos State University Teaching Hospital (26.3%), and Lagos University Teaching Hospital (17.5%) were mostly female (98.4%). Mean age was 48.8 years ± 11.79. Three hundred twenty-two (86.6%) patients and first-degree relatives were willing to take the test, of whom 231 (71.1%) were willing to pay for it. more than half (53.6%) of the participants were willing to pay between N10,000 and N30,000, which is less than $100 US dollars. Sociodemographic variables and willingness to test showed no association (P > .05). Education and ethnicity were found to be associated with their willingness to pay for CGT (P ≤ .05).CONCLUSIONLearning clinically relevant details toward cancer prevention informs health-related decisions in patients and relatives, a motivator for willingness to pay for genetic testing in low- and middle-income countries. Increased awareness may influence outcomes of cancer risk management. |
| first_indexed | 2024-04-10T06:36:39Z |
| format | Article |
| id | doaj.art-b4e4a1ec3de2472e9b2ec72a473cc187 |
| institution | Directory Open Access Journal |
| issn | 2687-8941 |
| language | English |
| last_indexed | 2024-04-10T06:36:39Z |
| publishDate | 2023-02-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj.art-b4e4a1ec3de2472e9b2ec72a473cc1872023-02-28T21:00:09ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412023-02-01910.1200/GO.21.00140Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic TestingPrisca O. Adejumo0Toyin I.G. Aniagwu1Olutosin A. Awolude2Babatunde Adedokun3Makayla Kochheiser4Anthonia Sowunmi5Abiodun Popoola6Oladosu Ojengbede7Dezheng Huo8Olufunmilayo I. Olopade9Department of Nursing, College of Medicine, University of Ibadan, NigeriaSchool of Occupational Health Nursing, University College Hospital, Ibadan, NigeriaDepartment of Obstetrics and Gynaecology, University College Hospital, Ibadan, Oyo, NigeriaCenter for Clinical Cancer Genetics & Global Health, Department of Medicine, The University of Chicago, Chicago, ILCenter for Clinical Cancer Genetics & Global Health, Department of Medicine, The University of Chicago, Chicago, ILLagos State University Teaching Hospital, Lagos, NigeriaLagos State University Teaching Hospital, Lagos, NigeriaCenter for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Oyo, NigeriaDepartment of Public Health Sciences, The University of Chicago, Chicago, ILCenter for Clinical Cancer Genetics & Global Health, Department of Medicine, The University of Chicago, Chicago, ILPURPOSECancer genetic testing (CGT), a pathway to personalized medicine, is also being embraced in Nigeria. However, little is known about the influence of demographics and perceptions on individuals' willingness to access and pay for CGT. This study assessed patients' willingness to undergo CGT in southwest Nigeria as a catalyst for sustainable Cancer Risk Management Program.METHODSThis was a cross-sectional study using semistructured questionnaire to interview 362 patients with cancer and 10 referred first-degree relatives between July 2018 and February 2020. Participants from three Nigerian teaching hospitals—University College Hospital, Ibadan, Lagos State University Teaching Hospital, Lagos, and Lagos University Teaching Hospital, Lagos, received genetic counseling and had subsequent CGT. Primary outcomes were willingness to undergo CGT in determining cancer risk and the willingness to pay for it. Ethical approval was from appropriate ethics committees of participating hospitals. Data were analyzed with SPSS version 22. Univariate comparison of categorical variables was performed by χ2 test, multivariate analysis by logistic regression.RESULTSThe participants from University College Hospital (56.2%), Lagos State University Teaching Hospital (26.3%), and Lagos University Teaching Hospital (17.5%) were mostly female (98.4%). Mean age was 48.8 years ± 11.79. Three hundred twenty-two (86.6%) patients and first-degree relatives were willing to take the test, of whom 231 (71.1%) were willing to pay for it. more than half (53.6%) of the participants were willing to pay between N10,000 and N30,000, which is less than $100 US dollars. Sociodemographic variables and willingness to test showed no association (P > .05). Education and ethnicity were found to be associated with their willingness to pay for CGT (P ≤ .05).CONCLUSIONLearning clinically relevant details toward cancer prevention informs health-related decisions in patients and relatives, a motivator for willingness to pay for genetic testing in low- and middle-income countries. Increased awareness may influence outcomes of cancer risk management.https://ascopubs.org/doi/10.1200/GO.21.00140 |
| spellingShingle | Prisca O. Adejumo Toyin I.G. Aniagwu Olutosin A. Awolude Babatunde Adedokun Makayla Kochheiser Anthonia Sowunmi Abiodun Popoola Oladosu Ojengbede Dezheng Huo Olufunmilayo I. Olopade Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing JCO Global Oncology |
| title | Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing |
| title_full | Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing |
| title_fullStr | Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing |
| title_full_unstemmed | Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing |
| title_short | Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing |
| title_sort | cancer genetic services in a low to middle income country cross sectional survey assessing willingness to undergo and pay for germline genetic testing |
| url | https://ascopubs.org/doi/10.1200/GO.21.00140 |
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