Sildenafil restores endothelial function in the apolipoprotein E knockout mouse

Sildenafil restores endothelial function in the apolipoprotein E knockout mouse

<p>Abstract</p> <p>Background</p> <p>Atherosclerosis is an inflammatory process of the arterial walls and is initiated by endothelial dysfunction accompanied by an imbalance in the production of reactive oxygen species (ROS) and nitric oxide (NO). Sildenafil, a selectiv...

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Bibliographic Details
Main Authors: Balarini Camille M, Leal Marcos A, Gomes Isabele B S, Pereira Thiago M C, Gava Agata L, Meyrelles Silvana S, Vasquez Elisardo C
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Journal of Translational Medicine
Subjects:
Atherosclerosis
ApoE knockout mice
Sildenafil
Nitric oxide
Oxidative stress
Endothelial dysfunction
PDE5
cGMP
Online Access:http://www.translational-medicine.com/content/11/1/3

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