Comparative evaluation of autosomal STRs and X-chromosome STRs as a complement of autosomal STRs in kinship testing in Southern Han Chinese
Nowadays, kinship testing is very common in forensic caseworks, but the power of autosomal short tandem repeats (A-STRs) may be limited in complex cases. X-Chromosome short tandem repeats (X-STRs), having a unique heritage mode, should be of special use in some deficient cases. To evaluate and compa...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Human Biology |
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| Online Access: | http://dx.doi.org/10.1080/03014460.2020.1856926 |
| _version_ | 1797685588387692544 |
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| author | Yinming Zhang Zhengliang Yu Xiaoting Mo Xingchun Zhao Wanshui Li Hong Liu Chao Liu Riga Wu Hongyu Sun |
| author_facet | Yinming Zhang Zhengliang Yu Xiaoting Mo Xingchun Zhao Wanshui Li Hong Liu Chao Liu Riga Wu Hongyu Sun |
| author_sort | Yinming Zhang |
| collection | DOAJ |
| description | Nowadays, kinship testing is very common in forensic caseworks, but the power of autosomal short tandem repeats (A-STRs) may be limited in complex cases. X-Chromosome short tandem repeats (X-STRs), having a unique heritage mode, should be of special use in some deficient cases. To evaluate and compare the potential of A-STR and X-STR as supplement genetic markers in deficient kinship testing, we simulated 10,000 duos for each of 18 kinds of relationships involving full sibling, half-sibling, grandparent-grandchild, and uncle/aunt-nephew/niece. Loci from STRTyper10, PowerPlex 16, and Investigator Argus X-12 were studied in Southern Han Chinese and the distribution of likelihood ratio (LR) values was analysed. With the addition of the X-12 system, the distribution of LR values for the full sisters, paternal half-sisters, paternal grandmother-granddaughters, maternal aunt-nieces, and maternal aunt-nephews separated much more obviously from those of unrelated duos, and the effectiveness was 1.0000, 0.99865, 0.9991, 0.8996 and 0.9634, respectively, which was more efficient than A-STRs. For the individual duos with other relationships, the effects of adding X-STRs and A-STRs were similar. Therefore, for the Southern Han Chinese, X-STRs can be very useful in kinship testing involving full sisters, paternal half-sisters, paternal grandmother-granddaughters, and maternal aunt-nieces/nephews. |
| first_indexed | 2024-03-12T00:46:20Z |
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| id | doaj.art-b4e55ea955c443608dcd06227f2d4294 |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-12T00:46:20Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-b4e55ea955c443608dcd06227f2d42942023-09-14T15:36:13ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332021-01-01481666910.1080/03014460.2020.18569261856926Comparative evaluation of autosomal STRs and X-chromosome STRs as a complement of autosomal STRs in kinship testing in Southern Han ChineseYinming Zhang0Zhengliang Yu1Xiaoting Mo2Xingchun Zhao3Wanshui Li4Hong Liu5Chao Liu6Riga Wu7Hongyu Sun8Institute of Forensic Science, Ministry of Public SecurityInstitute of Forensic Science, Ministry of Public SecurityInstitute of Forensic Science, Ministry of Public SecurityInstitute of Forensic Science, Ministry of Public SecurityInstitute of Forensic Science, Ministry of Public SecurityGuangzhou Forensic InstituteGuangzhou Forensic InstituteFaculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen UniversityFaculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen UniversityNowadays, kinship testing is very common in forensic caseworks, but the power of autosomal short tandem repeats (A-STRs) may be limited in complex cases. X-Chromosome short tandem repeats (X-STRs), having a unique heritage mode, should be of special use in some deficient cases. To evaluate and compare the potential of A-STR and X-STR as supplement genetic markers in deficient kinship testing, we simulated 10,000 duos for each of 18 kinds of relationships involving full sibling, half-sibling, grandparent-grandchild, and uncle/aunt-nephew/niece. Loci from STRTyper10, PowerPlex 16, and Investigator Argus X-12 were studied in Southern Han Chinese and the distribution of likelihood ratio (LR) values was analysed. With the addition of the X-12 system, the distribution of LR values for the full sisters, paternal half-sisters, paternal grandmother-granddaughters, maternal aunt-nieces, and maternal aunt-nephews separated much more obviously from those of unrelated duos, and the effectiveness was 1.0000, 0.99865, 0.9991, 0.8996 and 0.9634, respectively, which was more efficient than A-STRs. For the individual duos with other relationships, the effects of adding X-STRs and A-STRs were similar. Therefore, for the Southern Han Chinese, X-STRs can be very useful in kinship testing involving full sisters, paternal half-sisters, paternal grandmother-granddaughters, and maternal aunt-nieces/nephews.http://dx.doi.org/10.1080/03014460.2020.1856926kinship testingrelationship testingautosomal strx-chromosome str |
| spellingShingle | Yinming Zhang Zhengliang Yu Xiaoting Mo Xingchun Zhao Wanshui Li Hong Liu Chao Liu Riga Wu Hongyu Sun Comparative evaluation of autosomal STRs and X-chromosome STRs as a complement of autosomal STRs in kinship testing in Southern Han Chinese Annals of Human Biology kinship testing relationship testing autosomal str x-chromosome str |
| title | Comparative evaluation of autosomal STRs and X-chromosome STRs as a complement of autosomal STRs in kinship testing in Southern Han Chinese |
| title_full | Comparative evaluation of autosomal STRs and X-chromosome STRs as a complement of autosomal STRs in kinship testing in Southern Han Chinese |
| title_fullStr | Comparative evaluation of autosomal STRs and X-chromosome STRs as a complement of autosomal STRs in kinship testing in Southern Han Chinese |
| title_full_unstemmed | Comparative evaluation of autosomal STRs and X-chromosome STRs as a complement of autosomal STRs in kinship testing in Southern Han Chinese |
| title_short | Comparative evaluation of autosomal STRs and X-chromosome STRs as a complement of autosomal STRs in kinship testing in Southern Han Chinese |
| title_sort | comparative evaluation of autosomal strs and x chromosome strs as a complement of autosomal strs in kinship testing in southern han chinese |
| topic | kinship testing relationship testing autosomal str x-chromosome str |
| url | http://dx.doi.org/10.1080/03014460.2020.1856926 |
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