Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase

Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase

The enzyme model, mouse acetylcholinesterase, which exhibits its active site at the bottom of a narrow gorge, was investigated in the presence of different concentrations of sucrose to shed light on the protein and water dynamics in cholinesterases. The study was conducted by incoherent neutron scat...

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Bibliographic Details
Main Authors: Sofya V. Lushchekina, Gaetan Inidjel, Nicolas Martinez, Patrick Masson, Marie Trovaslet-Leroy, Florian Nachon, Michael Marek Koza, Tilo Seydel, Judith Peters
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomolecules
Subjects:
cholinesterase
osmotic stress
neutron scattering
molecular dynamics
MD simulations
Online Access:https://www.mdpi.com/2218-273X/10/12/1664

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