Bile acid receptors and renal regulation of water homeostasis
The kidney is the key organ responsible for maintaining the body’s water and electrolyte homeostasis. About 99% of the primary urine filtered from the Bowman’s capsule is reabsorbed along various renal tubules every day, with only 1–2 L of urine excreted. Aquaporins (AQPs) play a vital role in water...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1322288/full |
| _version_ | 1827752081727946752 |
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| author | Yanlin Guo Yanlin Guo Taotao Luo Guixiang Xie Xiaoyan Zhang Xiaoyan Zhang |
| author_facet | Yanlin Guo Yanlin Guo Taotao Luo Guixiang Xie Xiaoyan Zhang Xiaoyan Zhang |
| author_sort | Yanlin Guo |
| collection | DOAJ |
| description | The kidney is the key organ responsible for maintaining the body’s water and electrolyte homeostasis. About 99% of the primary urine filtered from the Bowman’s capsule is reabsorbed along various renal tubules every day, with only 1–2 L of urine excreted. Aquaporins (AQPs) play a vital role in water reabsorption in the kidney. Currently, a variety of molecules are found to be involved in the process of urine concentration by regulating the expression or activity of AQPs, such as antidiuretic hormone, renin-angiotensin-aldosterone system (RAAS), prostaglandin, and several nuclear receptors. As the main bile acid receptors, farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor 1 (TGR5) play important roles in bile acid, glucose, lipid, and energy metabolism. In the kidney, FXR and TGR5 exhibit broad expression across all segments of renal tubules, and their activation holds significant therapeutic potential for numerous acute and chronic kidney diseases through alleviating renal lipid accumulation, inflammation, oxidative stress, and fibrosis. Emerging evidence has demonstrated that the genetic deletion of FXR or TGR5 exhibits increased basal urine output, suggesting that bile acid receptors play a critical role in urine concentration. Here, we briefly summarize the function of bile acid receptors in renal water reabsorption and urine concentration. |
| first_indexed | 2024-03-11T07:06:50Z |
| format | Article |
| id | doaj.art-b4e702b987c3495794dd600d3e4154de |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-11T07:06:50Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b4e702b987c3495794dd600d3e4154de2023-11-17T08:55:48ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-11-011410.3389/fphys.2023.13222881322288Bile acid receptors and renal regulation of water homeostasisYanlin Guo0Yanlin Guo1Taotao Luo2Guixiang Xie3Xiaoyan Zhang4Xiaoyan Zhang5Division of Nephrology, Wuhu Hospital, East China Normal University, Wuhu, ChinaHealth Science Center, East China Normal University, Shanghai, ChinaDivision of Nephrology, Wuhu Hospital, East China Normal University, Wuhu, ChinaDivision of Nephrology, Wuhu Hospital, East China Normal University, Wuhu, ChinaDivision of Nephrology, Wuhu Hospital, East China Normal University, Wuhu, ChinaHealth Science Center, East China Normal University, Shanghai, ChinaThe kidney is the key organ responsible for maintaining the body’s water and electrolyte homeostasis. About 99% of the primary urine filtered from the Bowman’s capsule is reabsorbed along various renal tubules every day, with only 1–2 L of urine excreted. Aquaporins (AQPs) play a vital role in water reabsorption in the kidney. Currently, a variety of molecules are found to be involved in the process of urine concentration by regulating the expression or activity of AQPs, such as antidiuretic hormone, renin-angiotensin-aldosterone system (RAAS), prostaglandin, and several nuclear receptors. As the main bile acid receptors, farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor 1 (TGR5) play important roles in bile acid, glucose, lipid, and energy metabolism. In the kidney, FXR and TGR5 exhibit broad expression across all segments of renal tubules, and their activation holds significant therapeutic potential for numerous acute and chronic kidney diseases through alleviating renal lipid accumulation, inflammation, oxidative stress, and fibrosis. Emerging evidence has demonstrated that the genetic deletion of FXR or TGR5 exhibits increased basal urine output, suggesting that bile acid receptors play a critical role in urine concentration. Here, we briefly summarize the function of bile acid receptors in renal water reabsorption and urine concentration.https://www.frontiersin.org/articles/10.3389/fphys.2023.1322288/fullFXRtgr5aquaporinkidneywater homeostasis |
| spellingShingle | Yanlin Guo Yanlin Guo Taotao Luo Guixiang Xie Xiaoyan Zhang Xiaoyan Zhang Bile acid receptors and renal regulation of water homeostasis Frontiers in Physiology FXR tgr5 aquaporin kidney water homeostasis |
| title | Bile acid receptors and renal regulation of water homeostasis |
| title_full | Bile acid receptors and renal regulation of water homeostasis |
| title_fullStr | Bile acid receptors and renal regulation of water homeostasis |
| title_full_unstemmed | Bile acid receptors and renal regulation of water homeostasis |
| title_short | Bile acid receptors and renal regulation of water homeostasis |
| title_sort | bile acid receptors and renal regulation of water homeostasis |
| topic | FXR tgr5 aquaporin kidney water homeostasis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1322288/full |
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