Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties
We propose an experimental technique for the estimation of quality parameters of post-mortem human bone samples with signs of osteoporosis. Since we were interested in characterizing bone microstructure by evaluating porosity, trabecular thickness, and space, we obtained reference values of those pa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/12/5479 |
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| author | Gerardo Presbítero David Gutiérrez Wendy Ruth Lemus-Martínez José Félix Vilchez Pedro García Ana Arizmendi-Morquecho |
| author_facet | Gerardo Presbítero David Gutiérrez Wendy Ruth Lemus-Martínez José Félix Vilchez Pedro García Ana Arizmendi-Morquecho |
| author_sort | Gerardo Presbítero |
| collection | DOAJ |
| description | We propose an experimental technique for the estimation of quality parameters of post-mortem human bone samples with signs of osteoporosis. Since we were interested in characterizing bone microstructure by evaluating porosity, trabecular thickness, and space, we obtained reference values of those parameters for some of our samples through micro-computerized tomography (micro-CT). Nevertheless, as such technology is not widely available, here we used a 2D imaging approximation of those quality parameters. We based our estimation on simple digital microscopy and calibrated to ensure a percentage of similarity higher than 95% in comparison to those values achieved through micro-CT. Additionally, we subjected our samples to mechanical testing to obtain a complete characterization of our samples and to provide a preliminary assessment of the possible relationship between clinical tests of bone mineral density (BMD) and bone quality parameters. Our results show that BMD may have very low specificity in the assessment of the authentic microstructure of bone, then a broader analysis of quality parameters is required to enhance the reliability of future osteoporosis diagnosis technologies. |
| first_indexed | 2024-03-10T10:27:38Z |
| format | Article |
| id | doaj.art-b4e79d30151a4112985bcd4b38551f33 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T10:27:38Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-b4e79d30151a4112985bcd4b38551f332023-11-21T23:56:43ZengMDPI AGApplied Sciences2076-34172021-06-011112547910.3390/app11125479Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical PropertiesGerardo Presbítero0David Gutiérrez1Wendy Ruth Lemus-Martínez2José Félix Vilchez3Pedro García4Ana Arizmendi-Morquecho5Centro de Ingeniería y Desarrollo Industrial (CIDESI), Sede Nuevo León, Apodaca 66600, MexicoCentro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Monterrey, Apodaca 66600, MexicoCentro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Monterrey, Apodaca 66600, MexicoFacultad de Medicina, Universidad Autónoma de Nuevo León (UANL), Monterrey 64460, MexicoFacultad de Medicina, Universidad Autónoma de Nuevo León (UANL), Monterrey 64460, MexicoCentro de Investigación en Materiales Avanzados S. C. (CIMAV), Unidad Monterrey, Apodaca 66628, MexicoWe propose an experimental technique for the estimation of quality parameters of post-mortem human bone samples with signs of osteoporosis. Since we were interested in characterizing bone microstructure by evaluating porosity, trabecular thickness, and space, we obtained reference values of those parameters for some of our samples through micro-computerized tomography (micro-CT). Nevertheless, as such technology is not widely available, here we used a 2D imaging approximation of those quality parameters. We based our estimation on simple digital microscopy and calibrated to ensure a percentage of similarity higher than 95% in comparison to those values achieved through micro-CT. Additionally, we subjected our samples to mechanical testing to obtain a complete characterization of our samples and to provide a preliminary assessment of the possible relationship between clinical tests of bone mineral density (BMD) and bone quality parameters. Our results show that BMD may have very low specificity in the assessment of the authentic microstructure of bone, then a broader analysis of quality parameters is required to enhance the reliability of future osteoporosis diagnosis technologies.https://www.mdpi.com/2076-3417/11/12/5479trabecular bonebone mineral densitymicro-CTbone quality parametersosteoporosis |
| spellingShingle | Gerardo Presbítero David Gutiérrez Wendy Ruth Lemus-Martínez José Félix Vilchez Pedro García Ana Arizmendi-Morquecho Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties Applied Sciences trabecular bone bone mineral density micro-CT bone quality parameters osteoporosis |
| title | Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties |
| title_full | Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties |
| title_fullStr | Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties |
| title_full_unstemmed | Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties |
| title_short | Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties |
| title_sort | assessment of quality in osteoporotic human trabecular bone and its relationship to mechanical properties |
| topic | trabecular bone bone mineral density micro-CT bone quality parameters osteoporosis |
| url | https://www.mdpi.com/2076-3417/11/12/5479 |
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