Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms
Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a gradual loss of skeletal muscle, leading to the decline of muscle strength and physical performance. Growing evidence suggests that the prevalence of sarcopenia increases in patients with heart failure (HF), whi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/10/2284 |
| _version_ | 1827704446660902912 |
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| author | Jinkyung Cho Youngju Choi Pavol Sajgalik Mi-Hyun No Sang-Hyun Lee Sujin Kim Jun-Won Heo Eun-Jeong Cho Eunwook Chang Ju-Hee Kang Hyo-Bum Kwak Dong-Ho Park |
| author_facet | Jinkyung Cho Youngju Choi Pavol Sajgalik Mi-Hyun No Sang-Hyun Lee Sujin Kim Jun-Won Heo Eun-Jeong Cho Eunwook Chang Ju-Hee Kang Hyo-Bum Kwak Dong-Ho Park |
| author_sort | Jinkyung Cho |
| collection | DOAJ |
| description | Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a gradual loss of skeletal muscle, leading to the decline of muscle strength and physical performance. Growing evidence suggests that the prevalence of sarcopenia increases in patients with heart failure (HF), which is a dominant pathogenesis in the aging heart. HF causes diverse metabolic complications that may result in sarcopenia. Therefore, sarcopenia may act as a strong predictor of frailty, disability, and mortality associated with HF. Currently, standard treatments for slowing muscle loss in patients with HF are not available. Therefore, here, we review the pathophysiological mechanisms underlying sarcopenia in HF as well as current knowledge regarding the beneficial effects of exercise on sarcopenia in HF and related mechanisms, including hormonal changes, myostatin, oxidative stress, inflammation, apoptosis, autophagy, the ubiquitin-proteasome system, and insulin resistance. |
| first_indexed | 2024-03-10T15:39:47Z |
| format | Article |
| id | doaj.art-b4e9491bc29a4df9b5f35931f1efe1b9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:39:47Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b4e9491bc29a4df9b5f35931f1efe1b92023-11-20T16:55:40ZengMDPI AGCells2073-44092020-10-01910228410.3390/cells9102284Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying MechanismsJinkyung Cho0Youngju Choi1Pavol Sajgalik2Mi-Hyun No3Sang-Hyun Lee4Sujin Kim5Jun-Won Heo6Eun-Jeong Cho7Eunwook Chang8Ju-Hee Kang9Hyo-Bum Kwak10Dong-Ho Park11Institute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester MN 55905, USAProgram in Biomedical Science & Engineering, Department of Kinesiology, Department of Biomedical Science, Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaInstitute of Sports & Arts Convergence (ISAC), Inha University, Incheon 22212, KoreaSarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a gradual loss of skeletal muscle, leading to the decline of muscle strength and physical performance. Growing evidence suggests that the prevalence of sarcopenia increases in patients with heart failure (HF), which is a dominant pathogenesis in the aging heart. HF causes diverse metabolic complications that may result in sarcopenia. Therefore, sarcopenia may act as a strong predictor of frailty, disability, and mortality associated with HF. Currently, standard treatments for slowing muscle loss in patients with HF are not available. Therefore, here, we review the pathophysiological mechanisms underlying sarcopenia in HF as well as current knowledge regarding the beneficial effects of exercise on sarcopenia in HF and related mechanisms, including hormonal changes, myostatin, oxidative stress, inflammation, apoptosis, autophagy, the ubiquitin-proteasome system, and insulin resistance.https://www.mdpi.com/2073-4409/9/10/2284sarcopeniaheart failureexerciseolder adults |
| spellingShingle | Jinkyung Cho Youngju Choi Pavol Sajgalik Mi-Hyun No Sang-Hyun Lee Sujin Kim Jun-Won Heo Eun-Jeong Cho Eunwook Chang Ju-Hee Kang Hyo-Bum Kwak Dong-Ho Park Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms Cells sarcopenia heart failure exercise older adults |
| title | Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms |
| title_full | Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms |
| title_fullStr | Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms |
| title_full_unstemmed | Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms |
| title_short | Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms |
| title_sort | exercise as a therapeutic strategy for sarcopenia in heart failure insights into underlying mechanisms |
| topic | sarcopenia heart failure exercise older adults |
| url | https://www.mdpi.com/2073-4409/9/10/2284 |
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