Core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis: a randomized prospective study
The aim of this study was to investigate the safety of injection of bone marrow aspirate concentrate during core decompression and to study its clinical (visual analogue scale; Harris-Hip-score) and radiological outcomes (magnetic resonance imaging). In this prospective and randomized clinical trial...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Open Medical Publishing
2016-03-01
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| Series: | Orthopedic Reviews |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/or/article/view/6162 |
| _version_ | 1818948113530880000 |
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| author | Wojciech Pepke Philip Kasten Nicholas Beckmann Patricia Janicki Marcus Egermann |
| author_facet | Wojciech Pepke Philip Kasten Nicholas Beckmann Patricia Janicki Marcus Egermann |
| author_sort | Wojciech Pepke |
| collection | DOAJ |
| description | The aim of this study was to investigate the safety of injection of bone marrow aspirate concentrate during core decompression and to study its clinical (visual analogue scale; Harris-Hip-score) and radiological outcomes (magnetic resonance imaging). In this prospective and randomized clinical trial we evaluated 24 consecutive patients with nontraumatic femoral head necrosis (FHN) during a period of two years after intervention. In vitro analysis of mesenchymal stem cells was performed by evaluating the fibroblast colony forming units (CFU-Fs). Postoperatively, significant decrease in pain associated with a functional benefit lasting was observed. However, there was no difference in the clinical outcome between the two study groups. Over the period of two years there was no significant difference between the head survival rate between both groups. In contrast to that, we could not perceive any significant change in the volume of FHN in both treatment groups related to the longitudinal course after treating. The number of CFU showed a significant increase after centrifugation. This trial could not detect a benefit from the additional injection of bone marrow concentrate with regard to bone regeneration and clinical outcome in the short term. |
| first_indexed | 2024-12-20T08:41:38Z |
| format | Article |
| id | doaj.art-b4e9c817e8a8480597a8efc05a43bd4b |
| institution | Directory Open Access Journal |
| issn | 2035-8237 2035-8164 |
| language | English |
| last_indexed | 2024-12-20T08:41:38Z |
| publishDate | 2016-03-01 |
| publisher | Open Medical Publishing |
| record_format | Article |
| series | Orthopedic Reviews |
| spelling | doaj.art-b4e9c817e8a8480597a8efc05a43bd4b2022-12-21T19:46:22ZengOpen Medical PublishingOrthopedic Reviews2035-82372035-81642016-03-018110.4081/or.2016.61623288Core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis: a randomized prospective studyWojciech Pepke0Philip Kasten1Nicholas Beckmann2Patricia Janicki3Marcus Egermann4Clinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University HospitalOrthopedic Surgery Center, TübingenClinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University HospitalClinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University HospitalClinic for Orthopedics and Trauma Surgery, St. Vincenz and Elisabeth Hospital MainzThe aim of this study was to investigate the safety of injection of bone marrow aspirate concentrate during core decompression and to study its clinical (visual analogue scale; Harris-Hip-score) and radiological outcomes (magnetic resonance imaging). In this prospective and randomized clinical trial we evaluated 24 consecutive patients with nontraumatic femoral head necrosis (FHN) during a period of two years after intervention. In vitro analysis of mesenchymal stem cells was performed by evaluating the fibroblast colony forming units (CFU-Fs). Postoperatively, significant decrease in pain associated with a functional benefit lasting was observed. However, there was no difference in the clinical outcome between the two study groups. Over the period of two years there was no significant difference between the head survival rate between both groups. In contrast to that, we could not perceive any significant change in the volume of FHN in both treatment groups related to the longitudinal course after treating. The number of CFU showed a significant increase after centrifugation. This trial could not detect a benefit from the additional injection of bone marrow concentrate with regard to bone regeneration and clinical outcome in the short term.http://www.pagepress.org/journals/index.php/or/article/view/6162Femoral head necrosiscore decompressionmesenchymal stem cellsautologous bone marrow concentrate |
| spellingShingle | Wojciech Pepke Philip Kasten Nicholas Beckmann Patricia Janicki Marcus Egermann Core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis: a randomized prospective study Orthopedic Reviews Femoral head necrosis core decompression mesenchymal stem cells autologous bone marrow concentrate |
| title | Core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis: a randomized prospective study |
| title_full | Core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis: a randomized prospective study |
| title_fullStr | Core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis: a randomized prospective study |
| title_full_unstemmed | Core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis: a randomized prospective study |
| title_short | Core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis: a randomized prospective study |
| title_sort | core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis a randomized prospective study |
| topic | Femoral head necrosis core decompression mesenchymal stem cells autologous bone marrow concentrate |
| url | http://www.pagepress.org/journals/index.php/or/article/view/6162 |
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