Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis
BackgroundEvidence from longitudinal studies has shown that influenza infection is linked to an increased risk of arrhythmia. Therefore, we aimed to assess the role of influenza vaccination in arrhythmia prevention.Materials and methodsThe PubMed, Embase, and Cochrane Library databases were searched...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.970533/full |
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| author | Menglu Liu Weichun Lin Tiangang Song Huilei Zhao Jianyong Ma Yujie Zhao Peng Yu Zhiwei Yan |
| author_facet | Menglu Liu Weichun Lin Tiangang Song Huilei Zhao Jianyong Ma Yujie Zhao Peng Yu Zhiwei Yan |
| author_sort | Menglu Liu |
| collection | DOAJ |
| description | BackgroundEvidence from longitudinal studies has shown that influenza infection is linked to an increased risk of arrhythmia. Therefore, we aimed to assess the role of influenza vaccination in arrhythmia prevention.Materials and methodsThe PubMed, Embase, and Cochrane Library databases were searched to identify studies that investigated the potential effects of the influenza vaccine on arrhythmia risk published until October 25th, 2021. The study was registered with PROSPERO (CRD42022300815).ResultsOne RCT with 2,532 patients and six observational studies with 3,167,445 patients were included. One RCT demonstrated a non-significant benefit of the influenza vaccine against arrhythmias [odds ratio (OR) = 0.43, 95% confidence interval (CI): 0.11–1.64; P = 0.20] in patients after myocardial infarction or those with high-risk stable coronary heart disease. A meta-analysis based on observational studies showed that vaccination was associated with a significantly lower risk of arrhythmia (OR: 0.82, 95% CI: 0.70–0.97; P = 0.02; I2 = 76%). Additionally, subgroup analysis showed a decreased risk of atrial fibrillation (AF) (OR: 0.94, 95% CI: 0.90–0.98; P = 0.006; I2 = 0%) and a non-significant but positive trend concerning ventricular arrhythmias (VAs) (OR: 0.68, 95% CI: 0.42–1.11; P = 0.12; I2 = 85%) after influenza vaccination.ConclusionBased on the current evidence, influenza vaccination may be associated with a reduced risk of arrhythmia, especially AF. Influenza vaccination may be an effective tool for the prevention of arrhythmias. The effect of influenza vaccination on the risk of VAs and arrhythmias in patients at low risk for cardiovascular diseases should be further studied.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42022300815]. |
| first_indexed | 2024-04-12T16:27:42Z |
| format | Article |
| id | doaj.art-b4eace9ed8ab49fc8b46733c85b5b32b |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T16:27:42Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b4eace9ed8ab49fc8b46733c85b5b32b2022-12-22T03:25:20ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-10-01910.3389/fcvm.2022.970533970533Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysisMenglu Liu0Weichun Lin1Tiangang Song2Huilei Zhao3Jianyong Ma4Yujie Zhao5Peng Yu6Zhiwei Yan7Department of Cardiology, Seventh People’s Hospital of Zhengzhou, Zhengzhou, ChinaDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Anesthesiology, The Third Hospital of Nanchang, Nanchang, ChinaDepartment of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, OH, United StatesDepartment of Cardiology, Seventh People’s Hospital of Zhengzhou, Zhengzhou, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Sports Rehabilitation, College of Human Kinesiology, Shenyang Sport University, Shenyang, ChinaBackgroundEvidence from longitudinal studies has shown that influenza infection is linked to an increased risk of arrhythmia. Therefore, we aimed to assess the role of influenza vaccination in arrhythmia prevention.Materials and methodsThe PubMed, Embase, and Cochrane Library databases were searched to identify studies that investigated the potential effects of the influenza vaccine on arrhythmia risk published until October 25th, 2021. The study was registered with PROSPERO (CRD42022300815).ResultsOne RCT with 2,532 patients and six observational studies with 3,167,445 patients were included. One RCT demonstrated a non-significant benefit of the influenza vaccine against arrhythmias [odds ratio (OR) = 0.43, 95% confidence interval (CI): 0.11–1.64; P = 0.20] in patients after myocardial infarction or those with high-risk stable coronary heart disease. A meta-analysis based on observational studies showed that vaccination was associated with a significantly lower risk of arrhythmia (OR: 0.82, 95% CI: 0.70–0.97; P = 0.02; I2 = 76%). Additionally, subgroup analysis showed a decreased risk of atrial fibrillation (AF) (OR: 0.94, 95% CI: 0.90–0.98; P = 0.006; I2 = 0%) and a non-significant but positive trend concerning ventricular arrhythmias (VAs) (OR: 0.68, 95% CI: 0.42–1.11; P = 0.12; I2 = 85%) after influenza vaccination.ConclusionBased on the current evidence, influenza vaccination may be associated with a reduced risk of arrhythmia, especially AF. Influenza vaccination may be an effective tool for the prevention of arrhythmias. The effect of influenza vaccination on the risk of VAs and arrhythmias in patients at low risk for cardiovascular diseases should be further studied.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42022300815].https://www.frontiersin.org/articles/10.3389/fcvm.2022.970533/fullinfluenza vaccinationarrhythmiaatrial fibrillationventricular arrhythmiameta-analysis |
| spellingShingle | Menglu Liu Weichun Lin Tiangang Song Huilei Zhao Jianyong Ma Yujie Zhao Peng Yu Zhiwei Yan Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis Frontiers in Cardiovascular Medicine influenza vaccination arrhythmia atrial fibrillation ventricular arrhythmia meta-analysis |
| title | Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis |
| title_full | Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis |
| title_fullStr | Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis |
| title_full_unstemmed | Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis |
| title_short | Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis |
| title_sort | influenza vaccination is associated with a decreased risk of atrial fibrillation a systematic review and meta analysis |
| topic | influenza vaccination arrhythmia atrial fibrillation ventricular arrhythmia meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.970533/full |
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