MTR, MTRR and CBS gene polymorphisms in recurrent miscarriages: A case control study from North India
Context: According to various epidemiological studies, the aetiology of recurrent miscarriages (RMs) is multifactorial. The goal of this study is to learn more about the link between genetic polymorphisms and RM. Aim: To evaluate the association of 5-Methytetrahydrofolate-Homocysteine Methyltransfer...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2022;volume=15;issue=2;spage=191;epage=196;aulast=Talwar |
| _version_ | 1818047441589501952 |
|---|---|
| author | Seerat Talwar Sweta Prasad Lovejeet Kaur Jyoti Mishra Manju Puri Mohinder Pal Sachdeva Kallur Nava Saraswathy |
| author_facet | Seerat Talwar Sweta Prasad Lovejeet Kaur Jyoti Mishra Manju Puri Mohinder Pal Sachdeva Kallur Nava Saraswathy |
| author_sort | Seerat Talwar |
| collection | DOAJ |
| description | Context: According to various epidemiological studies, the aetiology of recurrent miscarriages (RMs) is multifactorial. The goal of this study is to learn more about the link between genetic polymorphisms and RM. Aim: To evaluate the association of 5-Methytetrahydrofolate-Homocysteine Methyltransferase (MTR) A2756G, 5-Methytetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR) A66G and cystathionine beta-synthase (CBS) 844INS68 genetic polymorphisms with RM and also to understand the combined effect of the selected genotypes. Setting and Design: This was a hospital-based, case–control, observational study. Materials and Methods: A total of 516 participants were recruited in the present study, of which 200 RM cases and 258 controls were included in the present study. Fasting blood sample (~5ml) was drawn from all the participants and were screened for genetic polymorphisms of MTR A2756G, MTRR A66G and CBS 844INS68. Statistical Analysis Used: The frequency, odd's ratio and Hardy-Weinberg equilibrium were evaluated. SPSS (version 21.0) was used for the data analysis. Results: MTR A2756G genetic polymorphism was not associated with the risk of RM. The ancestral allele of MTRR A66G and the mutant allele of CBS 844INS68 was causing an increased risk of more than two folds for RM. CBS 844INS68 in combination with MTR A2756G was found to pose an increased risk of more than two folds for RM. Conclusion: Genetic polymorphisms particularly MTRR A66G and CBS 844INS68 seems to be elevating the risk and hence making women susceptible for RM. |
| first_indexed | 2024-12-10T10:05:51Z |
| format | Article |
| id | doaj.art-b4eb8d2f1b45471cb86b8ca4761f6d7c |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-10T10:05:51Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-b4eb8d2f1b45471cb86b8ca4761f6d7c2022-12-22T01:53:15ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662022-01-0115219119610.4103/jhrs.jhrs_186_21MTR, MTRR and CBS gene polymorphisms in recurrent miscarriages: A case control study from North IndiaSeerat TalwarSweta PrasadLovejeet KaurJyoti MishraManju PuriMohinder Pal SachdevaKallur Nava SaraswathyContext: According to various epidemiological studies, the aetiology of recurrent miscarriages (RMs) is multifactorial. The goal of this study is to learn more about the link between genetic polymorphisms and RM. Aim: To evaluate the association of 5-Methytetrahydrofolate-Homocysteine Methyltransferase (MTR) A2756G, 5-Methytetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR) A66G and cystathionine beta-synthase (CBS) 844INS68 genetic polymorphisms with RM and also to understand the combined effect of the selected genotypes. Setting and Design: This was a hospital-based, case–control, observational study. Materials and Methods: A total of 516 participants were recruited in the present study, of which 200 RM cases and 258 controls were included in the present study. Fasting blood sample (~5ml) was drawn from all the participants and were screened for genetic polymorphisms of MTR A2756G, MTRR A66G and CBS 844INS68. Statistical Analysis Used: The frequency, odd's ratio and Hardy-Weinberg equilibrium were evaluated. SPSS (version 21.0) was used for the data analysis. Results: MTR A2756G genetic polymorphism was not associated with the risk of RM. The ancestral allele of MTRR A66G and the mutant allele of CBS 844INS68 was causing an increased risk of more than two folds for RM. CBS 844INS68 in combination with MTR A2756G was found to pose an increased risk of more than two folds for RM. Conclusion: Genetic polymorphisms particularly MTRR A66G and CBS 844INS68 seems to be elevating the risk and hence making women susceptible for RM.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2022;volume=15;issue=2;spage=191;epage=196;aulast=Talwar5-methytetrahydrofolate-homocysteine methyltransferase a2756g5-methytetrahydrofolate-homocysteine methyltransferase reductase a66gcbs 844ins68gene-gene interactiongenetic polymorphismrecurrent miscarriage |
| spellingShingle | Seerat Talwar Sweta Prasad Lovejeet Kaur Jyoti Mishra Manju Puri Mohinder Pal Sachdeva Kallur Nava Saraswathy MTR, MTRR and CBS gene polymorphisms in recurrent miscarriages: A case control study from North India Journal of Human Reproductive Sciences 5-methytetrahydrofolate-homocysteine methyltransferase a2756g 5-methytetrahydrofolate-homocysteine methyltransferase reductase a66g cbs 844ins68 gene-gene interaction genetic polymorphism recurrent miscarriage |
| title | MTR, MTRR and CBS gene polymorphisms in recurrent miscarriages: A case control study from North India |
| title_full | MTR, MTRR and CBS gene polymorphisms in recurrent miscarriages: A case control study from North India |
| title_fullStr | MTR, MTRR and CBS gene polymorphisms in recurrent miscarriages: A case control study from North India |
| title_full_unstemmed | MTR, MTRR and CBS gene polymorphisms in recurrent miscarriages: A case control study from North India |
| title_short | MTR, MTRR and CBS gene polymorphisms in recurrent miscarriages: A case control study from North India |
| title_sort | mtr mtrr and cbs gene polymorphisms in recurrent miscarriages a case control study from north india |
| topic | 5-methytetrahydrofolate-homocysteine methyltransferase a2756g 5-methytetrahydrofolate-homocysteine methyltransferase reductase a66g cbs 844ins68 gene-gene interaction genetic polymorphism recurrent miscarriage |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2022;volume=15;issue=2;spage=191;epage=196;aulast=Talwar |
| work_keys_str_mv | AT seerattalwar mtrmtrrandcbsgenepolymorphismsinrecurrentmiscarriagesacasecontrolstudyfromnorthindia AT swetaprasad mtrmtrrandcbsgenepolymorphismsinrecurrentmiscarriagesacasecontrolstudyfromnorthindia AT lovejeetkaur mtrmtrrandcbsgenepolymorphismsinrecurrentmiscarriagesacasecontrolstudyfromnorthindia AT jyotimishra mtrmtrrandcbsgenepolymorphismsinrecurrentmiscarriagesacasecontrolstudyfromnorthindia AT manjupuri mtrmtrrandcbsgenepolymorphismsinrecurrentmiscarriagesacasecontrolstudyfromnorthindia AT mohinderpalsachdeva mtrmtrrandcbsgenepolymorphismsinrecurrentmiscarriagesacasecontrolstudyfromnorthindia AT kallurnavasaraswathy mtrmtrrandcbsgenepolymorphismsinrecurrentmiscarriagesacasecontrolstudyfromnorthindia |