EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS

Objective. To study the effect of the protective agent ethylmethylhydroxypyridine malate on the numbers of erythroblastic islets in rats exposed to sulfur-containing gases. Materials and methods. Natural sulfur-containing gas mixtures from the Astrakhan gas-condensate field were used to model the ga...

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Main Authors: O. A. Ovsyannikova, D. V. Karpeeva, M. D. Osipenko
Format: Article
Language:Russian
Published: IRBIS LLC 2017-08-01
Series:Акушерство, гинекология и репродукция
Subjects:
Online Access:https://www.gynecology.su/jour/article/view/408
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author O. A. Ovsyannikova
D. V. Karpeeva
M. D. Osipenko
author_facet O. A. Ovsyannikova
D. V. Karpeeva
M. D. Osipenko
author_sort O. A. Ovsyannikova
collection DOAJ
description Objective. To study the effect of the protective agent ethylmethylhydroxypyridine malate on the numbers of erythroblastic islets in rats exposed to sulfur-containing gases. Materials and methods. Natural sulfur-containing gas mixtures from the Astrakhan gas-condensate field were used to model the gas-polluted environment. Male rats of various ages simulated different stages of postnatal human ontogenesis. Results. The obtained results indicate that at all stages of ontogenesis ethylmethylhydroxypyridine malate protected erythroblastic islets from intoxication by gaseous sulfur pollutants and led to partial normalization of proliferation and maturation of eryth rob lasts. Conclusion. The protective action of ethylmethylhydroxypyridine malate may be used for neutralizing the biological damage caused by toxic air pollutants at different stages of ontogenesis.
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spelling doaj.art-b4ebd012129f42948fee1bd5a082cfc82023-03-13T07:09:49ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942017-08-01112232810.17749/2313-7347.2017.11.2.023-028389EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESISO. A. Ovsyannikova0D. V. Karpeeva1M. D. Osipenko2Astrakhan State Medical University, Health Ministry of Russian FederationAstrakhan State Medical University, Health Ministry of Russian FederationAstrakhan State Medical University, Health Ministry of Russian FederationObjective. To study the effect of the protective agent ethylmethylhydroxypyridine malate on the numbers of erythroblastic islets in rats exposed to sulfur-containing gases. Materials and methods. Natural sulfur-containing gas mixtures from the Astrakhan gas-condensate field were used to model the gas-polluted environment. Male rats of various ages simulated different stages of postnatal human ontogenesis. Results. The obtained results indicate that at all stages of ontogenesis ethylmethylhydroxypyridine malate protected erythroblastic islets from intoxication by gaseous sulfur pollutants and led to partial normalization of proliferation and maturation of eryth rob lasts. Conclusion. The protective action of ethylmethylhydroxypyridine malate may be used for neutralizing the biological damage caused by toxic air pollutants at different stages of ontogenesis.https://www.gynecology.su/jour/article/view/408erythropoiesissulfur dioxideethylmethylhydroxypyridine malateratsstages of ontogeny
spellingShingle O. A. Ovsyannikova
D. V. Karpeeva
M. D. Osipenko
EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS
Акушерство, гинекология и репродукция
erythropoiesis
sulfur dioxide
ethylmethylhydroxypyridine malate
rats
stages of ontogeny
title EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS
title_full EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS
title_fullStr EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS
title_full_unstemmed EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS
title_short EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS
title_sort effect of ethylmethylhydroxypyridine malate on the absolute numbers of erythroblastic islets in rats exposed to sulfur contaning gas at different stages of postnatal ontogenesis
topic erythropoiesis
sulfur dioxide
ethylmethylhydroxypyridine malate
rats
stages of ontogeny
url https://www.gynecology.su/jour/article/view/408
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AT dvkarpeeva effectofethylmethylhydroxypyridinemalateontheabsolutenumbersoferythroblasticisletsinratsexposedtosulfurcontaninggasatdifferentstagesofpostnatalontogenesis
AT mdosipenko effectofethylmethylhydroxypyridinemalateontheabsolutenumbersoferythroblasticisletsinratsexposedtosulfurcontaninggasatdifferentstagesofpostnatalontogenesis