Protective effect of bone marrow mesenchymal stem cells modified with klotho on renal ischemia-reperfusion injury

Protective effect of bone marrow mesenchymal stem cells modified with klotho on renal ischemia-reperfusion injury

Objective: To detect the combination protective effect of bone marrow mesenchymal stem cells (BMSCs) and Klotho gene on the renal ischemia-reperfusion injury (RIRI). Methods: BMSCs isolated from rats were transfected with Klotho gene to form BMSCKl. We injected BMSCKl to allogenic rat RIRI model. Af...

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Bibliographic Details
Main Authors: Li-Bo Xie, Xi Chen, Bo Chen, Xian-Ding Wang, Rui Jiang, Yi-Ping Lu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Renal Failure
Subjects:
renal ischemia-reperfusion injury
bone marrow mesenchymal stem cells
gene transfection
klotho
foxo1
Online Access:http://dx.doi.org/10.1080/0886022X.2019.1588131

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