Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases
The review highlights various aspects of the influence of chaperones on amyloid proteins associated with the development of neurodegenerative diseases and includes studies conducted in our laboratory. Different sections of the article are devoted to the role of chaperones in the pathological transfo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/5/2747 |
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| author | Vladimir I. Muronetz Sofia S. Kudryavtseva Evgeniia V. Leisi Lidia P. Kurochkina Kseniya V. Barinova Elena V. Schmalhausen |
| author_facet | Vladimir I. Muronetz Sofia S. Kudryavtseva Evgeniia V. Leisi Lidia P. Kurochkina Kseniya V. Barinova Elena V. Schmalhausen |
| author_sort | Vladimir I. Muronetz |
| collection | DOAJ |
| description | The review highlights various aspects of the influence of chaperones on amyloid proteins associated with the development of neurodegenerative diseases and includes studies conducted in our laboratory. Different sections of the article are devoted to the role of chaperones in the pathological transformation of alpha-synuclein and the prion protein. Information about the interaction of the chaperonins GroE and TRiC as well as polymer-based artificial chaperones with amyloidogenic proteins is summarized. Particular attention is paid to the effect of blocking chaperones by misfolded and amyloidogenic proteins. It was noted that the accumulation of functionally inactive chaperones blocked by misfolded proteins might cause the formation of amyloid aggregates and prevent the disassembly of fibrillar structures. Moreover, the blocking of chaperones by various forms of amyloid proteins might lead to pathological changes in the vital activity of cells due to the impaired folding of newly synthesized proteins and their subsequent processing. The final section of the article discusses both the little data on the role of gut microbiota in the propagation of synucleinopathies and prion diseases and the possible involvement of the bacterial chaperone GroE in these processes. |
| first_indexed | 2024-03-09T20:37:15Z |
| format | Article |
| id | doaj.art-b4ef619a3d1343f0945ae4b03c11256e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:37:15Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b4ef619a3d1343f0945ae4b03c11256e2023-11-23T23:09:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01235274710.3390/ijms23052747Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative DiseasesVladimir I. Muronetz0Sofia S. Kudryavtseva1Evgeniia V. Leisi2Lidia P. Kurochkina3Kseniya V. Barinova4Elena V. Schmalhausen5Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, 119991 Moscow, RussiaBelozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, RussiaBelozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, RussiaBelozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, RussiaThe review highlights various aspects of the influence of chaperones on amyloid proteins associated with the development of neurodegenerative diseases and includes studies conducted in our laboratory. Different sections of the article are devoted to the role of chaperones in the pathological transformation of alpha-synuclein and the prion protein. Information about the interaction of the chaperonins GroE and TRiC as well as polymer-based artificial chaperones with amyloidogenic proteins is summarized. Particular attention is paid to the effect of blocking chaperones by misfolded and amyloidogenic proteins. It was noted that the accumulation of functionally inactive chaperones blocked by misfolded proteins might cause the formation of amyloid aggregates and prevent the disassembly of fibrillar structures. Moreover, the blocking of chaperones by various forms of amyloid proteins might lead to pathological changes in the vital activity of cells due to the impaired folding of newly synthesized proteins and their subsequent processing. The final section of the article discusses both the little data on the role of gut microbiota in the propagation of synucleinopathies and prion diseases and the possible involvement of the bacterial chaperone GroE in these processes.https://www.mdpi.com/1422-0067/23/5/2747alpha-synucleinamyloid proteinschaperoneschaperoninsmicrobiotamisfolded proteins |
| spellingShingle | Vladimir I. Muronetz Sofia S. Kudryavtseva Evgeniia V. Leisi Lidia P. Kurochkina Kseniya V. Barinova Elena V. Schmalhausen Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases International Journal of Molecular Sciences alpha-synuclein amyloid proteins chaperones chaperonins microbiota misfolded proteins |
| title | Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases |
| title_full | Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases |
| title_fullStr | Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases |
| title_full_unstemmed | Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases |
| title_short | Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases |
| title_sort | regulation by different types of chaperones of amyloid transformation of proteins involved in the development of neurodegenerative diseases |
| topic | alpha-synuclein amyloid proteins chaperones chaperonins microbiota misfolded proteins |
| url | https://www.mdpi.com/1422-0067/23/5/2747 |
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