Tinnitus Perception in Light of a Parietal Operculo–Insular Involvement: A Review
In tinnitus literature, researchers have increasingly been advocating for a clearer distinction between tinnitus perception and tinnitus-related distress. In non-bothersome tinnitus, the perception itself can be more specifically investigated: this has provided a body of evidence, based on resting-s...
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MDPI AG
2022-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/3/334 |
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| author | Chloé Jaroszynski Agnès Job Maciej Jedynak Olivier David Chantal Delon-Martin |
| author_facet | Chloé Jaroszynski Agnès Job Maciej Jedynak Olivier David Chantal Delon-Martin |
| author_sort | Chloé Jaroszynski |
| collection | DOAJ |
| description | In tinnitus literature, researchers have increasingly been advocating for a clearer distinction between tinnitus perception and tinnitus-related distress. In non-bothersome tinnitus, the perception itself can be more specifically investigated: this has provided a body of evidence, based on resting-state and activation fMRI protocols, highlighting the involvement of regions outside the conventional auditory areas, such as the right parietal operculum. Here, we aim to conduct a review of available investigations of the human parietal operculo–insular subregions conducted at the microscopic, mesoscopic, and macroscopic scales arguing in favor of an auditory–somatosensory cross-talk. Both the previous literature and new results on functional connectivity derived from cortico–cortical evoked potentials show that these subregions present a dense tissue of interconnections and a strong connectivity with auditory and somatosensory areas in the healthy brain. Disrupted integration processes between these modalities may thus result in erroneous perceptions, such as tinnitus. More precisely, we highlight the role of a subregion of the right parietal operculum, known as OP3 according to the Jülich atlas, in the integration of auditory and somatosensory representation of the orofacial muscles in the healthy population. We further discuss how a dysfunction of these muscles could induce hyperactivity in the OP3. The evidence of direct electrical stimulation of this area eliciting auditory hallucinations further suggests its involvement in tinnitus perception. Finally, a small number of neuroimaging studies of therapeutic interventions for tinnitus provide additional evidence of right parietal operculum involvement. |
| first_indexed | 2024-03-09T20:04:06Z |
| format | Article |
| id | doaj.art-b4efe1c1540348d483c0154fda2b8790 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T20:04:06Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-b4efe1c1540348d483c0154fda2b87902023-11-24T00:37:38ZengMDPI AGBrain Sciences2076-34252022-03-0112333410.3390/brainsci12030334Tinnitus Perception in Light of a Parietal Operculo–Insular Involvement: A ReviewChloé Jaroszynski0Agnès Job1Maciej Jedynak2Olivier David3Chantal Delon-Martin4University Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, FranceInstitut de Recherche Biomédicale des Armées, IRBA, 91220 Brétigny-sur-Orge, FranceUniversity Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, FranceUniversity Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, FranceUniversity Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, FranceIn tinnitus literature, researchers have increasingly been advocating for a clearer distinction between tinnitus perception and tinnitus-related distress. In non-bothersome tinnitus, the perception itself can be more specifically investigated: this has provided a body of evidence, based on resting-state and activation fMRI protocols, highlighting the involvement of regions outside the conventional auditory areas, such as the right parietal operculum. Here, we aim to conduct a review of available investigations of the human parietal operculo–insular subregions conducted at the microscopic, mesoscopic, and macroscopic scales arguing in favor of an auditory–somatosensory cross-talk. Both the previous literature and new results on functional connectivity derived from cortico–cortical evoked potentials show that these subregions present a dense tissue of interconnections and a strong connectivity with auditory and somatosensory areas in the healthy brain. Disrupted integration processes between these modalities may thus result in erroneous perceptions, such as tinnitus. More precisely, we highlight the role of a subregion of the right parietal operculum, known as OP3 according to the Jülich atlas, in the integration of auditory and somatosensory representation of the orofacial muscles in the healthy population. We further discuss how a dysfunction of these muscles could induce hyperactivity in the OP3. The evidence of direct electrical stimulation of this area eliciting auditory hallucinations further suggests its involvement in tinnitus perception. Finally, a small number of neuroimaging studies of therapeutic interventions for tinnitus provide additional evidence of right parietal operculum involvement.https://www.mdpi.com/2076-3425/12/3/334tinnitusparietal operculumOP3insulaintegration areaneuroimaging |
| spellingShingle | Chloé Jaroszynski Agnès Job Maciej Jedynak Olivier David Chantal Delon-Martin Tinnitus Perception in Light of a Parietal Operculo–Insular Involvement: A Review Brain Sciences tinnitus parietal operculum OP3 insula integration area neuroimaging |
| title | Tinnitus Perception in Light of a Parietal Operculo–Insular Involvement: A Review |
| title_full | Tinnitus Perception in Light of a Parietal Operculo–Insular Involvement: A Review |
| title_fullStr | Tinnitus Perception in Light of a Parietal Operculo–Insular Involvement: A Review |
| title_full_unstemmed | Tinnitus Perception in Light of a Parietal Operculo–Insular Involvement: A Review |
| title_short | Tinnitus Perception in Light of a Parietal Operculo–Insular Involvement: A Review |
| title_sort | tinnitus perception in light of a parietal operculo insular involvement a review |
| topic | tinnitus parietal operculum OP3 insula integration area neuroimaging |
| url | https://www.mdpi.com/2076-3425/12/3/334 |
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