Brain-Derived Microparticles (BDMPs) Contribute to Neuroinflammation and Lactadherin Reduces BDMP Induced Neuroinflammation and Improves Outcome After Stroke

Brain-Derived Microparticles (BDMPs) Contribute to Neuroinflammation and Lactadherin Reduces BDMP Induced Neuroinflammation and Improves Outcome After Stroke

Microparticles (MPs, ~size between 0.1 and 1 mm) are lipid encased containers derived from intact cells which contain antigen from the parent cells. MPs are involved in intercellular communication and regulate inflammation. Stroke increases secretion of brain derived MP (BDMP) which activate macroph...

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Bibliographic Details
Main Authors: Zhili Chen, Michael Chopp, Alex Zacharek, Wei Li, Poornima Venkat, Fenjie Wang, Julie Landschoot-Ward, Jieli Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
brain-derived microparticles
stroke
neuroinflammation
Lactadherin
therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02747/full

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