Deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangement
<p>Abstract</p> <p>Background</p> <p>When organismal phylogenies based on sequences of single marker genes are poorly resolved, a logical approach is to add more markers, on the assumption that weak but congruent phylogenetic signal will be reinforced in such multigene...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-04-01
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| Series: | BMC Evolutionary Biology |
| Online Access: | http://www.biomedcentral.com/1471-2148/5/27 |
| _version_ | 1818907413906980864 |
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| author | Charlebois Robert L MacLeod Dave Doolittle Ford Bapteste Eric |
| author_facet | Charlebois Robert L MacLeod Dave Doolittle Ford Bapteste Eric |
| author_sort | Charlebois Robert L |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>When organismal phylogenies based on sequences of single marker genes are poorly resolved, a logical approach is to add more markers, on the assumption that weak but congruent phylogenetic signal will be reinforced in such multigene trees. Such approaches are valid only when the several markers indeed have identical phylogenies, an issue which many multigene methods (such as the use of concatenated gene sequences or the assembly of supertrees) do not directly address. Indeed, even when the true history is a mixture of vertical descent for some genes and lateral gene transfer (LGT) for others, such methods produce unique topologies.</p> <p>Results</p> <p>We have developed software that aims to extract evidence for vertical and lateral inheritance from a set of gene trees compared against an arbitrary reference tree. This evidence is then displayed as a synthesis showing support over the tree for vertical inheritance, overlaid with explicit lateral gene transfer (LGT) events inferred to have occurred over the history of the tree. Like splits-tree methods, one can thus identify nodes at which conflict occurs. Additionally one can make reasonable inferences about vertical and lateral signal, assigning putative donors and recipients.</p> <p>Conclusion</p> <p>A tool such as ours can serve to explore the reticulated dimensionality of molecular evolution, by dissecting vertical and lateral inheritance at high resolution. By this, we mean that individual nodes can be examined not only for congruence, but also for coherence in light of LGT. We assert that our tools will facilitate the comparison of phylogenetic trees, and the interpretation of conflicting data.</p> |
| first_indexed | 2024-12-19T21:54:44Z |
| format | Article |
| id | doaj.art-b4f136fc27c541e2a1d362751df1975a |
| institution | Directory Open Access Journal |
| issn | 1471-2148 |
| language | English |
| last_indexed | 2024-12-19T21:54:44Z |
| publishDate | 2005-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Evolutionary Biology |
| spelling | doaj.art-b4f136fc27c541e2a1d362751df1975a2022-12-21T20:04:18ZengBMCBMC Evolutionary Biology1471-21482005-04-01512710.1186/1471-2148-5-27Deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangementCharlebois Robert LMacLeod DaveDoolittle FordBapteste Eric<p>Abstract</p> <p>Background</p> <p>When organismal phylogenies based on sequences of single marker genes are poorly resolved, a logical approach is to add more markers, on the assumption that weak but congruent phylogenetic signal will be reinforced in such multigene trees. Such approaches are valid only when the several markers indeed have identical phylogenies, an issue which many multigene methods (such as the use of concatenated gene sequences or the assembly of supertrees) do not directly address. Indeed, even when the true history is a mixture of vertical descent for some genes and lateral gene transfer (LGT) for others, such methods produce unique topologies.</p> <p>Results</p> <p>We have developed software that aims to extract evidence for vertical and lateral inheritance from a set of gene trees compared against an arbitrary reference tree. This evidence is then displayed as a synthesis showing support over the tree for vertical inheritance, overlaid with explicit lateral gene transfer (LGT) events inferred to have occurred over the history of the tree. Like splits-tree methods, one can thus identify nodes at which conflict occurs. Additionally one can make reasonable inferences about vertical and lateral signal, assigning putative donors and recipients.</p> <p>Conclusion</p> <p>A tool such as ours can serve to explore the reticulated dimensionality of molecular evolution, by dissecting vertical and lateral inheritance at high resolution. By this, we mean that individual nodes can be examined not only for congruence, but also for coherence in light of LGT. We assert that our tools will facilitate the comparison of phylogenetic trees, and the interpretation of conflicting data.</p>http://www.biomedcentral.com/1471-2148/5/27 |
| spellingShingle | Charlebois Robert L MacLeod Dave Doolittle Ford Bapteste Eric Deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangement BMC Evolutionary Biology |
| title | Deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangement |
| title_full | Deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangement |
| title_fullStr | Deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangement |
| title_full_unstemmed | Deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangement |
| title_short | Deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangement |
| title_sort | deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangement |
| url | http://www.biomedcentral.com/1471-2148/5/27 |
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