Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes
Abstract Background Verrucous vulvar carcinoma (VC) is an uncommon and distinct histologic subtype of squamous cell carcinoma (SCC). The available literature on VC is currently limited to case reports and small single institution studies. Aims The goals of this study were to analyze data from the Na...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.1591 |
| _version_ | 1817985102916878336 |
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| author | Sara M. Dryden Leonid B. Reshko Jeremy T. Gaskins Scott R. Silva |
| author_facet | Sara M. Dryden Leonid B. Reshko Jeremy T. Gaskins Scott R. Silva |
| author_sort | Sara M. Dryden |
| collection | DOAJ |
| description | Abstract Background Verrucous vulvar carcinoma (VC) is an uncommon and distinct histologic subtype of squamous cell carcinoma (SCC). The available literature on VC is currently limited to case reports and small single institution studies. Aims The goals of this study were to analyze data from the National Cancer Database (NCDB) to quantitate the incidence of VC and to investigate the effects of patient demographics, tumor characteristics, and treatment regimens on overall survival (OS) in women with verrucous vulvar carcinoma. Methods and results Patients diagnosed with vulvar SCC or VC between the years of 2004 and 2016 were identified in the NCDB. OS was assessed with Kaplan–Meier curves and the log‐rank test. Construction of a Cox model compared survival after controlling for confounding variables. The reported incidence of SCC of the vulva has significantly increased since 2004 (p < .0001). In contrast, the incidence of VC has remained stable (p = .344) since 2004. Compared to SCC, VC was significantly more likely to be diagnosed in older women (p < .0001) and treated with surgery alone (p < .0001). However, on propensity score weighted analysis there was a trend toward improved 5‐year OS in women with VC compared to those with SCC (63.4% vs. 57.7%, p = .0794). Multivariable Cox survival analysis showed an improvement in OS in VC patients treated with both primary site and regional lymph node surgery compared to primary site surgery alone (adjusted hazard ratio [aHR] 0.67, 95% confidence interval [CI] 0.46–0.97, p = .0357). Conclusion Verrucous carcinoma is more likely to present in older women. Regional lymph node surgery in addition to primary site surgery significantly improves OS in VC patients. |
| first_indexed | 2024-04-13T23:52:53Z |
| format | Article |
| id | doaj.art-b4f49f8e8cdc430ba5c77e45cd09fc00 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-13T23:52:53Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-b4f49f8e8cdc430ba5c77e45cd09fc002022-12-22T02:24:01ZengWileyCancer Reports2573-83482022-10-01510n/an/a10.1002/cnr2.1591Verrucous carcinoma of the vulva: Patterns of care and treatment outcomesSara M. Dryden0Leonid B. Reshko1Jeremy T. Gaskins2Scott R. Silva3Department of Radiation Oncology University of Louisville Louisville Kentucky USADepartment of Radiation Oncology University of Louisville Louisville Kentucky USADepartment of Bioinformatics & Biostatistics University of Louisville Louisville Kentucky USADepartment of Radiation Oncology University of Louisville Louisville Kentucky USAAbstract Background Verrucous vulvar carcinoma (VC) is an uncommon and distinct histologic subtype of squamous cell carcinoma (SCC). The available literature on VC is currently limited to case reports and small single institution studies. Aims The goals of this study were to analyze data from the National Cancer Database (NCDB) to quantitate the incidence of VC and to investigate the effects of patient demographics, tumor characteristics, and treatment regimens on overall survival (OS) in women with verrucous vulvar carcinoma. Methods and results Patients diagnosed with vulvar SCC or VC between the years of 2004 and 2016 were identified in the NCDB. OS was assessed with Kaplan–Meier curves and the log‐rank test. Construction of a Cox model compared survival after controlling for confounding variables. The reported incidence of SCC of the vulva has significantly increased since 2004 (p < .0001). In contrast, the incidence of VC has remained stable (p = .344) since 2004. Compared to SCC, VC was significantly more likely to be diagnosed in older women (p < .0001) and treated with surgery alone (p < .0001). However, on propensity score weighted analysis there was a trend toward improved 5‐year OS in women with VC compared to those with SCC (63.4% vs. 57.7%, p = .0794). Multivariable Cox survival analysis showed an improvement in OS in VC patients treated with both primary site and regional lymph node surgery compared to primary site surgery alone (adjusted hazard ratio [aHR] 0.67, 95% confidence interval [CI] 0.46–0.97, p = .0357). Conclusion Verrucous carcinoma is more likely to present in older women. Regional lymph node surgery in addition to primary site surgery significantly improves OS in VC patients.https://doi.org/10.1002/cnr2.1591gynecologic cancerNational Cancer Databaseverrucousvulva |
| spellingShingle | Sara M. Dryden Leonid B. Reshko Jeremy T. Gaskins Scott R. Silva Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes Cancer Reports gynecologic cancer National Cancer Database verrucous vulva |
| title | Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes |
| title_full | Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes |
| title_fullStr | Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes |
| title_full_unstemmed | Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes |
| title_short | Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes |
| title_sort | verrucous carcinoma of the vulva patterns of care and treatment outcomes |
| topic | gynecologic cancer National Cancer Database verrucous vulva |
| url | https://doi.org/10.1002/cnr2.1591 |
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