Inferring Single-Cell 3D Chromosomal Structures Based on the Lennard-Jones Potential

Inferring Single-Cell 3D Chromosomal Structures Based on the Lennard-Jones Potential

Reconstructing three-dimensional (3D) chromosomal structures based on single-cell Hi-C data is a challenging scientific problem due to the extreme sparseness of the single-cell Hi-C data. In this research, we used the Lennard-Jones potential to reconstruct both 500 kb and high-resolution 50 kb chrom...

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Bibliographic Details
Main Authors: Mengsheng Zha, Nan Wang, Chaoyang Zhang, Zheng Wang
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
3D genome
single-cell Hi-C
3D chromosomal structure
Lennard-Jones potential
Online Access:https://www.mdpi.com/1422-0067/22/11/5914

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