Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil
Few studies are available on hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection in populations living in small and medium-sized Brazilian cities. We evaluated the seroprevalence of these viruses in selected individuals from a clinic of infectology, w...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2009-11-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000700003 |
| _version_ | 1797703063455137792 |
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| author | Alexandre Martins Portelinha Filho Charles Ulloffo do Nascimento Talita Nicastro Tannouri Charlene Troiani Eloah Lopes Ascêncio Renata Bonfim Lourdes Aparecida Zampieri D'Andrea Luiz Euribel Prestes-Carneiro |
| author_facet | Alexandre Martins Portelinha Filho Charles Ulloffo do Nascimento Talita Nicastro Tannouri Charlene Troiani Eloah Lopes Ascêncio Renata Bonfim Lourdes Aparecida Zampieri D'Andrea Luiz Euribel Prestes-Carneiro |
| author_sort | Alexandre Martins Portelinha Filho |
| collection | DOAJ |
| description | Few studies are available on hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection in populations living in small and medium-sized Brazilian cities. We evaluated the seroprevalence of these viruses in selected individuals from a clinic of infectology, who were referred to the University Regional Hospital of the West Region of state of São Paulo, Brazil. Among a total of 7,021 individuals seen in the clinic following receipt of preliminary ELISA results or having the suggested clinical signs of viral hepatitis or HIV, 1,228 were systematically screened. Isolated or associated HBsAg, HCV and HIV antibodies were found in 44.9% of the subjects. Anti-HIV antibodies were found in 24.7% of the patients, 20.3% of whom had an HIV monoinfection and 4.4% of whom were co-infected with hepatitis viruses (HCV: 4%; HBV: 0.4%). Anti-HCV antibodies were found in 14% of the patients and 5.9% had anti-HBsAg antibodies. HCV infection affected males more than females (p < 0.05) and individuals > 50-years old had an increased prevalence of anti-HCV compared to HIV (p = 0.0001) or HBV (p = 0.0063). HCV-RNA was detected in 73.5% of the samples with a predominance of genotype 1 (72.5%). A significant percentage (44.9%) of the selected individuals was positive for antibodies against HBV, HCV and/or HIV; these patients would otherwise have remained undiagnosed. |
| first_indexed | 2024-03-12T04:58:59Z |
| format | Article |
| id | doaj.art-b4f8372e2bfb4aa0b8db415bb92bdf40 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T04:58:59Z |
| publishDate | 2009-11-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-b4f8372e2bfb4aa0b8db415bb92bdf402023-09-03T09:14:33ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602009-11-01104796096310.1590/S0074-02762009000700003Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, BrazilAlexandre Martins Portelinha FilhoCharles Ulloffo do NascimentoTalita Nicastro TannouriCharlene TroianiEloah Lopes AscêncioRenata BonfimLourdes Aparecida Zampieri D'AndreaLuiz Euribel Prestes-CarneiroFew studies are available on hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection in populations living in small and medium-sized Brazilian cities. We evaluated the seroprevalence of these viruses in selected individuals from a clinic of infectology, who were referred to the University Regional Hospital of the West Region of state of São Paulo, Brazil. Among a total of 7,021 individuals seen in the clinic following receipt of preliminary ELISA results or having the suggested clinical signs of viral hepatitis or HIV, 1,228 were systematically screened. Isolated or associated HBsAg, HCV and HIV antibodies were found in 44.9% of the subjects. Anti-HIV antibodies were found in 24.7% of the patients, 20.3% of whom had an HIV monoinfection and 4.4% of whom were co-infected with hepatitis viruses (HCV: 4%; HBV: 0.4%). Anti-HCV antibodies were found in 14% of the patients and 5.9% had anti-HBsAg antibodies. HCV infection affected males more than females (p < 0.05) and individuals > 50-years old had an increased prevalence of anti-HCV compared to HIV (p = 0.0001) or HBV (p = 0.0063). HCV-RNA was detected in 73.5% of the samples with a predominance of genotype 1 (72.5%). A significant percentage (44.9%) of the selected individuals was positive for antibodies against HBV, HCV and/or HIV; these patients would otherwise have remained undiagnosed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000700003hepatitis B virushepatitis C virushuman immunodeficiency virus co-infectionHCV genotypesseroprevalenceSão Paulo |
| spellingShingle | Alexandre Martins Portelinha Filho Charles Ulloffo do Nascimento Talita Nicastro Tannouri Charlene Troiani Eloah Lopes Ascêncio Renata Bonfim Lourdes Aparecida Zampieri D'Andrea Luiz Euribel Prestes-Carneiro Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil Memorias do Instituto Oswaldo Cruz hepatitis B virus hepatitis C virus human immunodeficiency virus co-infection HCV genotypes seroprevalence São Paulo |
| title | Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil |
| title_full | Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil |
| title_fullStr | Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil |
| title_full_unstemmed | Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil |
| title_short | Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil |
| title_sort | seroprevalence of hbv hcv and hiv co infection in selected individuals from state of sao paulo brazil |
| topic | hepatitis B virus hepatitis C virus human immunodeficiency virus co-infection HCV genotypes seroprevalence São Paulo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000700003 |
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