In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus
IntroductionSurveillance of the Seneca Valley virus (SVV) shows a disproportionately higher incidence on Chinese pig farms. Currently, there are no vaccines or drugs to treat SVV infection effectively and effective treatment options are urgently needed.MethodsIn this study, we evaluated the antivira...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.980187/full |
| _version_ | 1811176909749354496 |
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| author | Bo Su Yingjie Wang Shanqiu Jian Huaqiao Tang Huidan Deng Ling Zhu Xiaonan Zhao Jian Liu Huangzuo Cheng Lina Zhang Youjun Hu Zhiwen Xu |
| author_facet | Bo Su Yingjie Wang Shanqiu Jian Huaqiao Tang Huidan Deng Ling Zhu Xiaonan Zhao Jian Liu Huangzuo Cheng Lina Zhang Youjun Hu Zhiwen Xu |
| author_sort | Bo Su |
| collection | DOAJ |
| description | IntroductionSurveillance of the Seneca Valley virus (SVV) shows a disproportionately higher incidence on Chinese pig farms. Currently, there are no vaccines or drugs to treat SVV infection effectively and effective treatment options are urgently needed.MethodsIn this study, we evaluated the antiviral activity of the following medium-chain fatty acids (MCFAs) or triglycerides (MCTs) against SVV: caprylic acid, caprylic monoglyceride, capric monoglyceride, and monolaurin.ResultsIn vitro experiments showed that monolaurin inhibited viral replication by up to 80%, while in vivo studies showed that monolaurin reduced clinical manifestations, viral load, and organ damage in SVV-infected piglets. Monolaurin significantly reduced the release of inflammatory cytokines and promoted the release of interferon-γ, which enhanced the viral clearance activity of this type of MCFA.DiscussionTherefore, monolaurin is a potentially effective candidate for the treatment of SVV infection in pigs. |
| first_indexed | 2024-04-10T20:00:43Z |
| format | Article |
| id | doaj.art-b4f86c880a134ee2b510a38f57adf5e3 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-10T20:00:43Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-b4f86c880a134ee2b510a38f57adf5e32023-01-27T07:27:33ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-01-011010.3389/fvets.2023.980187980187In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virusBo Su0Yingjie Wang1Shanqiu Jian2Huaqiao Tang3Huidan Deng4Ling Zhu5Xiaonan Zhao6Jian Liu7Huangzuo Cheng8Lina Zhang9Youjun Hu10Zhiwen Xu11College of Veterinary Medicine, Sichaun Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichaun Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichaun Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichaun Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichaun Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichaun Agricultural University, Chengdu, ChinaInnovation Center of Guangdong Nuacid Biotechnology Co., Ltd., Qingyuan, ChinaInnovation Center of Guangdong Nuacid Biotechnology Co., Ltd., Qingyuan, ChinaInnovation Center of Guangdong Nuacid Biotechnology Co., Ltd., Qingyuan, ChinaCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, ChinaInnovation Center of Guangdong Nuacid Biotechnology Co., Ltd., Qingyuan, ChinaCollege of Veterinary Medicine, Sichaun Agricultural University, Chengdu, ChinaIntroductionSurveillance of the Seneca Valley virus (SVV) shows a disproportionately higher incidence on Chinese pig farms. Currently, there are no vaccines or drugs to treat SVV infection effectively and effective treatment options are urgently needed.MethodsIn this study, we evaluated the antiviral activity of the following medium-chain fatty acids (MCFAs) or triglycerides (MCTs) against SVV: caprylic acid, caprylic monoglyceride, capric monoglyceride, and monolaurin.ResultsIn vitro experiments showed that monolaurin inhibited viral replication by up to 80%, while in vivo studies showed that monolaurin reduced clinical manifestations, viral load, and organ damage in SVV-infected piglets. Monolaurin significantly reduced the release of inflammatory cytokines and promoted the release of interferon-γ, which enhanced the viral clearance activity of this type of MCFA.DiscussionTherefore, monolaurin is a potentially effective candidate for the treatment of SVV infection in pigs.https://www.frontiersin.org/articles/10.3389/fvets.2023.980187/fullMCFAantiviral agentmonolaurinSVVinflammatory response |
| spellingShingle | Bo Su Yingjie Wang Shanqiu Jian Huaqiao Tang Huidan Deng Ling Zhu Xiaonan Zhao Jian Liu Huangzuo Cheng Lina Zhang Youjun Hu Zhiwen Xu In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus Frontiers in Veterinary Science MCFA antiviral agent monolaurin SVV inflammatory response |
| title | In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus |
| title_full | In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus |
| title_fullStr | In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus |
| title_full_unstemmed | In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus |
| title_short | In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus |
| title_sort | in vitro and in vivo antiviral activity of monolaurin against seneca valley virus |
| topic | MCFA antiviral agent monolaurin SVV inflammatory response |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.980187/full |
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