<it>PNPLA 3</it> I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection
<p>Abstract</p> <p>Background</p> <p>Hepatic steatosis in HCV patients has been postulated as a risk factor associated with a higher frequency of fibrosis and cirrhosis. A single genetic variant, <it>PNPLA3</it> I148M, has been widely associated with increas...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-09-01
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| Series: | BMC Medical Genetics |
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| Online Access: | http://www.biomedcentral.com/1471-2350/13/82 |
| _version_ | 1818917490566103040 |
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| author | Rembeck Karolina Maglio Cristina Lagging Martin Christensen Peer Färkkilä Martti Langeland Nina Buhl Mads Pedersen Court Mørch Kristine Norkrans Gunnar Hellstrand Kristoffer Lindh Magnus Pirazzi Carlo Burza Maria Romeo Stefano Westin Johan |
| author_facet | Rembeck Karolina Maglio Cristina Lagging Martin Christensen Peer Färkkilä Martti Langeland Nina Buhl Mads Pedersen Court Mørch Kristine Norkrans Gunnar Hellstrand Kristoffer Lindh Magnus Pirazzi Carlo Burza Maria Romeo Stefano Westin Johan |
| author_sort | Rembeck Karolina |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Hepatic steatosis in HCV patients has been postulated as a risk factor associated with a higher frequency of fibrosis and cirrhosis. A single genetic variant, <it>PNPLA3</it> I148M, has been widely associated with increased hepatic steatosis. Previous studies of the <it>PNPLA3</it> I148M sequence variant in HCV infected individuals have reported an association between this variant and prevalence of steatosis, fibrosis, and cirrhosis. To evaluate the impact of <it>PNPLA3</it> I148M variant on metabolic traits and treatment response in HCV genotype 2 and 3 infected patients.</p> <p>Methods</p> <p>Three hundred and eighty-two treatment naïve HCV genotype 2 or 3 infected patients were included in a phase III, open label, randomized, multicenter, investigator-initiated trial (the NORDynamIC study), in which pretreatment liver biopsies were mandatory. <it>PNPLA3I148M</it> genotyping was performed in a total of 359 Caucasian patients.</p> <p>Results</p> <p>In HCV genotype 2 infected patients carrying the <it>PNPLA3</it> 148M allele, there was significantly increased insulin resistance (P = 0.023) and lower viral load (P = 0.005) at baseline as well as the first seven days of antiviral treatment. These results were not observed in HCV genotype 3 infected patients.</p> <p>Conclusions</p> <p>Our results suggest a possible association between the <it>PNPLA3</it> 148M allele and insulin resistance as well as baseline viral load in HCV genotype 2, but not in genotype 3.</p> |
| first_indexed | 2024-12-20T00:34:54Z |
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| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-20T00:34:54Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genetics |
| spelling | doaj.art-b4f983a8211a453a8772fd5053e521bb2022-12-21T19:59:48ZengBMCBMC Medical Genetics1471-23502012-09-011318210.1186/1471-2350-13-82<it>PNPLA 3</it> I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infectionRembeck KarolinaMaglio CristinaLagging MartinChristensen PeerFärkkilä MarttiLangeland NinaBuhl MadsPedersen CourtMørch KristineNorkrans GunnarHellstrand KristofferLindh MagnusPirazzi CarloBurza MariaRomeo StefanoWestin Johan<p>Abstract</p> <p>Background</p> <p>Hepatic steatosis in HCV patients has been postulated as a risk factor associated with a higher frequency of fibrosis and cirrhosis. A single genetic variant, <it>PNPLA3</it> I148M, has been widely associated with increased hepatic steatosis. Previous studies of the <it>PNPLA3</it> I148M sequence variant in HCV infected individuals have reported an association between this variant and prevalence of steatosis, fibrosis, and cirrhosis. To evaluate the impact of <it>PNPLA3</it> I148M variant on metabolic traits and treatment response in HCV genotype 2 and 3 infected patients.</p> <p>Methods</p> <p>Three hundred and eighty-two treatment naïve HCV genotype 2 or 3 infected patients were included in a phase III, open label, randomized, multicenter, investigator-initiated trial (the NORDynamIC study), in which pretreatment liver biopsies were mandatory. <it>PNPLA3I148M</it> genotyping was performed in a total of 359 Caucasian patients.</p> <p>Results</p> <p>In HCV genotype 2 infected patients carrying the <it>PNPLA3</it> 148M allele, there was significantly increased insulin resistance (P = 0.023) and lower viral load (P = 0.005) at baseline as well as the first seven days of antiviral treatment. These results were not observed in HCV genotype 3 infected patients.</p> <p>Conclusions</p> <p>Our results suggest a possible association between the <it>PNPLA3</it> 148M allele and insulin resistance as well as baseline viral load in HCV genotype 2, but not in genotype 3.</p>http://www.biomedcentral.com/1471-2350/13/82Hepatitis C<it>PNPLA 3</it>Insulin resistanceViral load |
| spellingShingle | Rembeck Karolina Maglio Cristina Lagging Martin Christensen Peer Färkkilä Martti Langeland Nina Buhl Mads Pedersen Court Mørch Kristine Norkrans Gunnar Hellstrand Kristoffer Lindh Magnus Pirazzi Carlo Burza Maria Romeo Stefano Westin Johan <it>PNPLA 3</it> I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection BMC Medical Genetics Hepatitis C <it>PNPLA 3</it> Insulin resistance Viral load |
| title | <it>PNPLA 3</it> I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection |
| title_full | <it>PNPLA 3</it> I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection |
| title_fullStr | <it>PNPLA 3</it> I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection |
| title_full_unstemmed | <it>PNPLA 3</it> I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection |
| title_short | <it>PNPLA 3</it> I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection |
| title_sort | it pnpla 3 it i148m genetic variant associates with insulin resistance and baseline viral load in hcv genotype 2 but not in genotype 3 infection |
| topic | Hepatitis C <it>PNPLA 3</it> Insulin resistance Viral load |
| url | http://www.biomedcentral.com/1471-2350/13/82 |
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