The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice
Myocardial substrate metabolism in cardiac hypertrophy or heart failure shifts from fatty acid oxidation to a greater reliance on glycolysis. Here, the authors show that KLF7 can simultaneously regulate key enzymes in glycolysis and fatty acid oxidation to mitigate metabolic imbalance during cardiac...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36712-9 |
| _version_ | 1797864159431360512 |
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| author | Cao Wang Shupei Qiao Yufang Zhao Hui Tian Wei Yan Xiaolu Hou Ruiqi Wang Bosong Zhang Chaofan Yang Fuxing Zhu Yanwen Jiao Jiaming Jin Yue Chen Weiming Tian |
| author_facet | Cao Wang Shupei Qiao Yufang Zhao Hui Tian Wei Yan Xiaolu Hou Ruiqi Wang Bosong Zhang Chaofan Yang Fuxing Zhu Yanwen Jiao Jiaming Jin Yue Chen Weiming Tian |
| author_sort | Cao Wang |
| collection | DOAJ |
| description | Myocardial substrate metabolism in cardiac hypertrophy or heart failure shifts from fatty acid oxidation to a greater reliance on glycolysis. Here, the authors show that KLF7 can simultaneously regulate key enzymes in glycolysis and fatty acid oxidation to mitigate metabolic imbalance during cardiac hypertrophy. |
| first_indexed | 2024-04-09T22:47:18Z |
| format | Article |
| id | doaj.art-b4f9c9375c62469fb5a9ad424daeeeb0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:47:18Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b4f9c9375c62469fb5a9ad424daeeeb02023-03-22T11:47:49ZengNature PortfolioNature Communications2041-17232023-02-0114111810.1038/s41467-023-36712-9The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male miceCao Wang0Shupei Qiao1Yufang Zhao2Hui Tian3Wei Yan4Xiaolu Hou5Ruiqi Wang6Bosong Zhang7Chaofan Yang8Fuxing Zhu9Yanwen Jiao10Jiaming Jin11Yue Chen12Weiming Tian13School of Life Science and Technology, Harbin Institute of TechnologyNHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical UniversitySpace Environment Simulation Research Infrastructure, Harbin Institute of TechnologySchool of Life Science and Technology, Harbin Institute of TechnologyDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Cardiology, The Fourth Affiliated Hospital of Harbin Medical UniversitySchool of Life Science and Technology, Harbin Institute of TechnologySchool of Life Science and Technology, Harbin Institute of TechnologySchool of Life Science and Technology, Harbin Institute of TechnologySchool of Life Science and Technology, Harbin Institute of TechnologySchool of Life Science and Technology, Harbin Institute of TechnologySchool of Life Science and Technology, Harbin Institute of TechnologySchool of Life Science and Technology, Harbin Institute of TechnologySchool of Life Science and Technology, Harbin Institute of TechnologyMyocardial substrate metabolism in cardiac hypertrophy or heart failure shifts from fatty acid oxidation to a greater reliance on glycolysis. Here, the authors show that KLF7 can simultaneously regulate key enzymes in glycolysis and fatty acid oxidation to mitigate metabolic imbalance during cardiac hypertrophy.https://doi.org/10.1038/s41467-023-36712-9 |
| spellingShingle | Cao Wang Shupei Qiao Yufang Zhao Hui Tian Wei Yan Xiaolu Hou Ruiqi Wang Bosong Zhang Chaofan Yang Fuxing Zhu Yanwen Jiao Jiaming Jin Yue Chen Weiming Tian The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice Nature Communications |
| title | The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice |
| title_full | The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice |
| title_fullStr | The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice |
| title_full_unstemmed | The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice |
| title_short | The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice |
| title_sort | klf7 pfkl acadl axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice |
| url | https://doi.org/10.1038/s41467-023-36712-9 |
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