Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis
Background: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis of this subgroup of cancer compared with other histologies. Methods: A sys...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/21/5191 |
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| author | Mariagiulia Dal Cero Maria Bencivenga Drolaiz H. W. Liu Michele Sacco Mariella Alloggio Kelly G. P. Kerckhoffs Federica Filippini Luca Saragoni Mar Iglesias Anna Tomezzoli Fátima Carneiro Heike I. Grabsch Giuseppe Verlato Lorena Torroni Guillaume Piessen Manuel Pera Giovanni de Manzoni |
| author_facet | Mariagiulia Dal Cero Maria Bencivenga Drolaiz H. W. Liu Michele Sacco Mariella Alloggio Kelly G. P. Kerckhoffs Federica Filippini Luca Saragoni Mar Iglesias Anna Tomezzoli Fátima Carneiro Heike I. Grabsch Giuseppe Verlato Lorena Torroni Guillaume Piessen Manuel Pera Giovanni de Manzoni |
| author_sort | Mariagiulia Dal Cero |
| collection | DOAJ |
| description | Background: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis of this subgroup of cancer compared with other histologies. Methods: A systematic literature search in the PubMed database was conducted, including all publications up to 1 October 2021. A meta-analysis comparing the results of the studies was performed. Results: A total of 2062 studies referring to gastric cancer with signet ring cell histology were identified, of which 262 studies reported on its relationship with clinical information. Of these, 74 were suitable to be included in the meta-analysis. A slightly lower risk of developing nodal metastases in signet ring cell tumours compared to other histotypes was found (especially to undifferentiated/poorly differentiated/mucinous and mixed histotypes); the lower risk was more evident in early and slightly increased in advanced gastric cancer. Survival tended to be better in early stage signet ring cell cancer compared to other histotypes; no differences were shown in advanced stages, and survival was poorer in metastatic patients. In the subgroup analysis, survival in signet ring cell cancer was slightly worse compared to non-signet ring cell cancer and differentiated/well-to-moderately differentiated adenocarcinoma. Conclusions: Most of the conflicting results in signet ring cell gastric cancer literature could be derived from the lack of standardisation in their classification and the comparison with the different subtypes of gastric cancer. There is a critical need to strive for a standardised classification system for gastric cancer, fostering clarity and coherence in the forthcoming research and clinical applications. |
| first_indexed | 2024-03-11T11:32:55Z |
| format | Article |
| id | doaj.art-b4fc4fd5b1e14eb580f7e5bc39d74b3a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T11:32:55Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b4fc4fd5b1e14eb580f7e5bc39d74b3a2023-11-10T15:00:11ZengMDPI AGCancers2072-66942023-10-011521519110.3390/cancers15215191Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-AnalysisMariagiulia Dal Cero0Maria Bencivenga1Drolaiz H. W. Liu2Michele Sacco3Mariella Alloggio4Kelly G. P. Kerckhoffs5Federica Filippini6Luca Saragoni7Mar Iglesias8Anna Tomezzoli9Fátima Carneiro10Heike I. Grabsch11Giuseppe Verlato12Lorena Torroni13Guillaume Piessen14Manuel Pera15Giovanni de Manzoni16General and Upper GI Surgery Division, Department of Surgery, University of Verona, Borgo Trento Hospital, Piazzale Stefani 1, 37124 Verona, ItalyGeneral and Upper GI Surgery Division, Department of Surgery, University of Verona, Borgo Trento Hospital, Piazzale Stefani 1, 37124 Verona, ItalyDepartment of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center, 6229 HX Maastricht, The NetherlandsGeneral and Upper GI Surgery Division, Department of Surgery, University of Verona, Borgo Trento Hospital, Piazzale Stefani 1, 37124 Verona, ItalyGeneral and Upper GI Surgery Division, Department of Surgery, University of Verona, Borgo Trento Hospital, Piazzale Stefani 1, 37124 Verona, ItalyDepartment of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center, 6229 HX Maastricht, The NetherlandsGeneral and Upper GI Surgery Division, Department of Surgery, University of Verona, Borgo Trento Hospital, Piazzale Stefani 1, 37124 Verona, ItalyPathology Unit, Morgagni-Pierantoni Hospital, 47100 Forlì, ItalyDepartment of Pathology, Hospital Universitario del Mar, Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, SpainDepartment of Pathology, Verona University Hospital, 37134 Verona, ItalyDepartment of Pathology, Medical Faculty of the University of Porto/Centro Hospitalar Universitário São João and Ipatimup/i3S, 4200-319 Porto, PortugalDepartment of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center, 6229 HX Maastricht, The NetherlandsUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37126 Verona, ItalyUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37126 Verona, ItalyDepartment of Digestive and Oncological Surgery, Lille University Hospital, 59000 Lille, FranceSection of Gastrointestinal Surgery, Hospital Universitario del Mar, Hospital del Mar Medical Research Institute (IMIM), Department of Surgery, Universitat Autònoma de Barcelona, 08003 Barcelona, SpainGeneral and Upper GI Surgery Division, Department of Surgery, University of Verona, Borgo Trento Hospital, Piazzale Stefani 1, 37124 Verona, ItalyBackground: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis of this subgroup of cancer compared with other histologies. Methods: A systematic literature search in the PubMed database was conducted, including all publications up to 1 October 2021. A meta-analysis comparing the results of the studies was performed. Results: A total of 2062 studies referring to gastric cancer with signet ring cell histology were identified, of which 262 studies reported on its relationship with clinical information. Of these, 74 were suitable to be included in the meta-analysis. A slightly lower risk of developing nodal metastases in signet ring cell tumours compared to other histotypes was found (especially to undifferentiated/poorly differentiated/mucinous and mixed histotypes); the lower risk was more evident in early and slightly increased in advanced gastric cancer. Survival tended to be better in early stage signet ring cell cancer compared to other histotypes; no differences were shown in advanced stages, and survival was poorer in metastatic patients. In the subgroup analysis, survival in signet ring cell cancer was slightly worse compared to non-signet ring cell cancer and differentiated/well-to-moderately differentiated adenocarcinoma. Conclusions: Most of the conflicting results in signet ring cell gastric cancer literature could be derived from the lack of standardisation in their classification and the comparison with the different subtypes of gastric cancer. There is a critical need to strive for a standardised classification system for gastric cancer, fostering clarity and coherence in the forthcoming research and clinical applications.https://www.mdpi.com/2072-6694/15/21/5191gastric cancersignet ring cellssurvivalpoorly cohesivepathological classification |
| spellingShingle | Mariagiulia Dal Cero Maria Bencivenga Drolaiz H. W. Liu Michele Sacco Mariella Alloggio Kelly G. P. Kerckhoffs Federica Filippini Luca Saragoni Mar Iglesias Anna Tomezzoli Fátima Carneiro Heike I. Grabsch Giuseppe Verlato Lorena Torroni Guillaume Piessen Manuel Pera Giovanni de Manzoni Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis Cancers gastric cancer signet ring cells survival poorly cohesive pathological classification |
| title | Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis |
| title_full | Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis |
| title_fullStr | Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis |
| title_full_unstemmed | Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis |
| title_short | Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis |
| title_sort | clinical features of gastric signet ring cell cancer results from a systematic review and meta analysis |
| topic | gastric cancer signet ring cells survival poorly cohesive pathological classification |
| url | https://www.mdpi.com/2072-6694/15/21/5191 |
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