Methamidophos poisoning: A paediatric case report
Methamidophos is a highly hazardous organophosphate and is known to cause an acute cholinergic toxidrome. Methamidophos use is not allowed in South Africa and therefore local data pertaining to methamidophos poisoning is very limited, with no paediatric clinical cases described. Methamidophos is an...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
|
| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750023001373 |
| _version_ | 1797390502973145088 |
|---|---|
| author | Pierre de Villiers Noor Parker Roland van Rensburg Pierre Goussard Carine Marks Veshni Pillay-Fuentes Lorente |
| author_facet | Pierre de Villiers Noor Parker Roland van Rensburg Pierre Goussard Carine Marks Veshni Pillay-Fuentes Lorente |
| author_sort | Pierre de Villiers |
| collection | DOAJ |
| description | Methamidophos is a highly hazardous organophosphate and is known to cause an acute cholinergic toxidrome. Methamidophos use is not allowed in South Africa and therefore local data pertaining to methamidophos poisoning is very limited, with no paediatric clinical cases described. Methamidophos is an active metabolite of acephate, a commonly used organophosphate, registered for agricultural use in South Africa. We present a paediatric case of methamidophos poisoning with prolonged clinical effects. The patient experienced a prolonged cholinergic toxidrome lasting 10 days, with a period of near-full recovery during this time. We discuss the biological plausibility of the detected methamidophos being a byproduct of acephate. In addition, we highlight the importance of closer monitoring of patients with organophosphate poisoning in areas where acephate is commonly used. |
| first_indexed | 2024-03-08T23:11:48Z |
| format | Article |
| id | doaj.art-b4fd5f8ebfcf4930988cbca2e54ed3d7 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-03-08T23:11:48Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-b4fd5f8ebfcf4930988cbca2e54ed3d72023-12-15T07:24:29ZengElsevierToxicology Reports2214-75002024-06-01121822Methamidophos poisoning: A paediatric case reportPierre de Villiers0Noor Parker1Roland van Rensburg2Pierre Goussard3Carine Marks4Veshni Pillay-Fuentes Lorente5Department of Paediatrics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Corresponding author.Department of Paediatrics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDivision of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDepartment of Paediatrics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDivision of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDivision of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaMethamidophos is a highly hazardous organophosphate and is known to cause an acute cholinergic toxidrome. Methamidophos use is not allowed in South Africa and therefore local data pertaining to methamidophos poisoning is very limited, with no paediatric clinical cases described. Methamidophos is an active metabolite of acephate, a commonly used organophosphate, registered for agricultural use in South Africa. We present a paediatric case of methamidophos poisoning with prolonged clinical effects. The patient experienced a prolonged cholinergic toxidrome lasting 10 days, with a period of near-full recovery during this time. We discuss the biological plausibility of the detected methamidophos being a byproduct of acephate. In addition, we highlight the importance of closer monitoring of patients with organophosphate poisoning in areas where acephate is commonly used.http://www.sciencedirect.com/science/article/pii/S2214750023001373OrganophosphateMethamidophosPaediatricsDermal absorptionProlonged cholinergic syndrome |
| spellingShingle | Pierre de Villiers Noor Parker Roland van Rensburg Pierre Goussard Carine Marks Veshni Pillay-Fuentes Lorente Methamidophos poisoning: A paediatric case report Toxicology Reports Organophosphate Methamidophos Paediatrics Dermal absorption Prolonged cholinergic syndrome |
| title | Methamidophos poisoning: A paediatric case report |
| title_full | Methamidophos poisoning: A paediatric case report |
| title_fullStr | Methamidophos poisoning: A paediatric case report |
| title_full_unstemmed | Methamidophos poisoning: A paediatric case report |
| title_short | Methamidophos poisoning: A paediatric case report |
| title_sort | methamidophos poisoning a paediatric case report |
| topic | Organophosphate Methamidophos Paediatrics Dermal absorption Prolonged cholinergic syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2214750023001373 |
| work_keys_str_mv | AT pierredevilliers methamidophospoisoningapaediatriccasereport AT noorparker methamidophospoisoningapaediatriccasereport AT rolandvanrensburg methamidophospoisoningapaediatriccasereport AT pierregoussard methamidophospoisoningapaediatriccasereport AT carinemarks methamidophospoisoningapaediatriccasereport AT veshnipillayfuenteslorente methamidophospoisoningapaediatriccasereport |