Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels
In this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogels, including the pore sizes, compression strength,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/2/271 |
| _version_ | 1797437594843217920 |
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| author | Zuwu Tang Meiqiong Yu Ajoy Kanti Mondal Xinxing Lin |
| author_facet | Zuwu Tang Meiqiong Yu Ajoy Kanti Mondal Xinxing Lin |
| author_sort | Zuwu Tang |
| collection | DOAJ |
| description | In this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogels, including the pore sizes, compression strength, lap shear strength, mass loss, and cytocompatibility were investigated. Scanning electron microscope images (SEM) displayed the hydrogel pore sizes, ranging from 20 to 100 μm. The composite hydrogel exhibited excellent porosity of 95.1%, compression strength of 5.2 MPa, lap shear strength of 21 kPa on porcine skin, and mass loss of 16.0%. In addition, the composite hydrogel possessed good relative cell activity of 97%. The PDA/CS/PVA hydrogel is cytocompatible as a starting point, and it can be further investigated in tissue engineering. |
| first_indexed | 2024-03-09T11:24:42Z |
| format | Article |
| id | doaj.art-b4fe643370de49b28d889d512168f813 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T11:24:42Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-b4fe643370de49b28d889d512168f8132023-12-01T00:07:05ZengMDPI AGPolymers2073-43602023-01-0115227110.3390/polym15020271Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite HydrogelsZuwu Tang0Meiqiong Yu1Ajoy Kanti Mondal2Xinxing Lin3School of Materials and Environmental Engineering, Fujian Polytechnic Normal University, No.1, Campus New Village, Longjiang Street, Fuzhou 350300, ChinaSchool of Materials and Environmental Engineering, Fujian Polytechnic Normal University, No.1, Campus New Village, Longjiang Street, Fuzhou 350300, ChinaLeather Research Institute, Bangladesh Council of Scientific and Industrial Research, Dhaka 1350, BangladeshSchool of Materials and Environmental Engineering, Fujian Polytechnic Normal University, No.1, Campus New Village, Longjiang Street, Fuzhou 350300, ChinaIn this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogels, including the pore sizes, compression strength, lap shear strength, mass loss, and cytocompatibility were investigated. Scanning electron microscope images (SEM) displayed the hydrogel pore sizes, ranging from 20 to 100 μm. The composite hydrogel exhibited excellent porosity of 95.1%, compression strength of 5.2 MPa, lap shear strength of 21 kPa on porcine skin, and mass loss of 16.0%. In addition, the composite hydrogel possessed good relative cell activity of 97%. The PDA/CS/PVA hydrogel is cytocompatible as a starting point, and it can be further investigated in tissue engineering.https://www.mdpi.com/2073-4360/15/2/271composite hydrogelcytocompatibilityporosityporous scaffolds |
| spellingShingle | Zuwu Tang Meiqiong Yu Ajoy Kanti Mondal Xinxing Lin Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels Polymers composite hydrogel cytocompatibility porosity porous scaffolds |
| title | Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels |
| title_full | Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels |
| title_fullStr | Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels |
| title_full_unstemmed | Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels |
| title_short | Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels |
| title_sort | porous scaffolds based on polydopamine chondroitin sulfate polyvinyl alcohol composite hydrogels |
| topic | composite hydrogel cytocompatibility porosity porous scaffolds |
| url | https://www.mdpi.com/2073-4360/15/2/271 |
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