Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortality
Background: To investigate the rate of all cause and cardiovascular mortality in patients with symptomatic or asymptomatic peripheral arterial disease (PAD) compared to those without PAD. Methods and results: All the subjects were inpatients at high risk of atherosclerosis and enrolled from February...
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| Format: | Article |
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SpringerOpen
2011-03-01
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| Series: | The Egyptian Heart Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110260811000238 |
| _version_ | 1818529149021585408 |
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| author | Eid M. Daoud Mahmoud M. Ramadan Nader El-Shahhat Ayman A. Abd El-Samad Nader El-Malkey Sherif A. Sakr Insaf Bassam Hazem Hakeem Asmaa Eneen Adel El-Badrawy |
| author_facet | Eid M. Daoud Mahmoud M. Ramadan Nader El-Shahhat Ayman A. Abd El-Samad Nader El-Malkey Sherif A. Sakr Insaf Bassam Hazem Hakeem Asmaa Eneen Adel El-Badrawy |
| author_sort | Eid M. Daoud |
| collection | DOAJ |
| description | Background: To investigate the rate of all cause and cardiovascular mortality in patients with symptomatic or asymptomatic peripheral arterial disease (PAD) compared to those without PAD.
Methods and results: All the subjects were inpatients at high risk of atherosclerosis and enrolled from February to November, 2006. A total of 320 were followed up until an end-point (death) was reached or until February 2010. The mean follow-up time was 37.7 ± 1.5 months. Compared with non-PAD, PAD patients had significantly higher rates of hypertension, diabetes mellitus, and smoking (P < 0.01). Those with symptomatic and asymptomatic PAD had a much higher all cause (37.5% and 23.0% vs. 12.1%) and cardiovascular mortality (18.8% and 13.8% vs. 6.7%) compared to those without PAD (P < 0.001). The symptomatic PAD patients were 1.831 times (95% CI: 1.222–2.741) as likely to die as those without PAD, and 1.646 times (95% CI: 1.301–2.083) in asymptomatic PAD patients after adjusting for other factors. Those with symptomatic or asymptomatic PAD were more than twice as likely to die of CVD as those without PAD (RR: 2.248, 95% CI: 1.366–3.698 and RR: 2.105, 95% CI: 1.566–2.831, respectively).
Conclusions: PAD was associated with a higher all cause and cardiovascular mortality whether or not PAD is symptomatic. |
| first_indexed | 2024-12-11T13:59:03Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1110-2608 |
| language | English |
| last_indexed | 2024-12-11T13:59:03Z |
| publishDate | 2011-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-b4febabe75594899a7e8f12d9e7225282022-12-22T01:03:56ZengSpringerOpenThe Egyptian Heart Journal1110-26082011-03-0163171210.1016/j.ehj.2011.08.022Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortalityEid M. Daoud0Mahmoud M. Ramadan1Nader El-Shahhat2Ayman A. Abd El-Samad3Nader El-Malkey4Sherif A. Sakr5Insaf Bassam6Hazem Hakeem7Asmaa Eneen8Adel El-Badrawy9Department of Cardiology, Faculty of Medicine, Mansoura University, EgyptDepartment of Cardiology, Faculty of Medicine, Mansoura University, EgyptDepartment of Cardiology, Faculty of Medicine, Mansoura University, EgyptDepartment of Cardiology, Faculty of Medicine, Mansoura University, EgyptDepartment of Internal Medicine, Faculty of Medicine, Mansoura University, EgyptDepartment of Cardiology, Faculty of Medicine, Mansoura University, EgyptDepartment of Internal Medicine, Faculty of Medicine, Mansoura University, EgyptDepartment of Internal Medicine, Faculty of Medicine, Mansoura University, EgyptDepartment of Internal Medicine, Faculty of Medicine, Mansoura University, EgyptDepartment of Radiology, Faculty of Medicine, Mansoura University, EgyptBackground: To investigate the rate of all cause and cardiovascular mortality in patients with symptomatic or asymptomatic peripheral arterial disease (PAD) compared to those without PAD. Methods and results: All the subjects were inpatients at high risk of atherosclerosis and enrolled from February to November, 2006. A total of 320 were followed up until an end-point (death) was reached or until February 2010. The mean follow-up time was 37.7 ± 1.5 months. Compared with non-PAD, PAD patients had significantly higher rates of hypertension, diabetes mellitus, and smoking (P < 0.01). Those with symptomatic and asymptomatic PAD had a much higher all cause (37.5% and 23.0% vs. 12.1%) and cardiovascular mortality (18.8% and 13.8% vs. 6.7%) compared to those without PAD (P < 0.001). The symptomatic PAD patients were 1.831 times (95% CI: 1.222–2.741) as likely to die as those without PAD, and 1.646 times (95% CI: 1.301–2.083) in asymptomatic PAD patients after adjusting for other factors. Those with symptomatic or asymptomatic PAD were more than twice as likely to die of CVD as those without PAD (RR: 2.248, 95% CI: 1.366–3.698 and RR: 2.105, 95% CI: 1.566–2.831, respectively). Conclusions: PAD was associated with a higher all cause and cardiovascular mortality whether or not PAD is symptomatic.http://www.sciencedirect.com/science/article/pii/S1110260811000238Peripheral arterial diseaseAnkle brachial indexAll-cause mortalityCardiovascular mortality |
| spellingShingle | Eid M. Daoud Mahmoud M. Ramadan Nader El-Shahhat Ayman A. Abd El-Samad Nader El-Malkey Sherif A. Sakr Insaf Bassam Hazem Hakeem Asmaa Eneen Adel El-Badrawy Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortality The Egyptian Heart Journal Peripheral arterial disease Ankle brachial index All-cause mortality Cardiovascular mortality |
| title | Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortality |
| title_full | Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortality |
| title_fullStr | Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortality |
| title_full_unstemmed | Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortality |
| title_short | Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortality |
| title_sort | associations of symptomatic or asymptomatic peripheral arterial disease with all cause mortality and cardiovascular mortality |
| topic | Peripheral arterial disease Ankle brachial index All-cause mortality Cardiovascular mortality |
| url | http://www.sciencedirect.com/science/article/pii/S1110260811000238 |
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