Allicin: A review of its important pharmacological activities
Background: Garlic (Allium sativum L.) is known for its synthesis of allicin, a defense molecule that exhibits various biological activities. Traditional medicine has utilized garlic to alleviate multiple ailments due to its broad spectrum of effects. Objective: This study aimed to review the ethnom...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142523000696 |
| _version_ | 1797682826279124992 |
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| author | Vivek D. Savairam Neha A. Patil Shrikant R. Borate Mahesh M. Ghaisas Rajkumar V. Shete |
| author_facet | Vivek D. Savairam Neha A. Patil Shrikant R. Borate Mahesh M. Ghaisas Rajkumar V. Shete |
| author_sort | Vivek D. Savairam |
| collection | DOAJ |
| description | Background: Garlic (Allium sativum L.) is known for its synthesis of allicin, a defense molecule that exhibits various biological activities. Traditional medicine has utilized garlic to alleviate multiple ailments due to its broad spectrum of effects. Objective: This study aimed to review the ethnomedicinal potentials and pharmacological activities of allicin, the active constituent of garlic. Method: A comprehensive review was conducted to analyze in vitro and in vivo studies on allicin. The focus was on investigating its diverse pharmacological properties, including neuroprotection, anti-alzheimer, anti-inflammatory, anticancer, antioxidant, cardio protective, antidiabetic, and hepatoprotection activity. Results: The review revealed that allicin possesses a range of pharmacological activities. It showed neuroprotective effects, exhibited anti-inflammatory properties, demonstrated anticancer activity, acted as an antioxidant, provided cardioprotection, exerted antidiabetic effects, and offered hepatoprotection. Conclusion: The findings of this study suggest that allicin holds great potential for pharmaceutical industries in developing therapeutic products. However, to ensure the safe and effective use of allicin for treating various diseases, further research is necessary. Human clinical trials and quality control studies are essential to establish appropriate doses for pharmaceutical applications. |
| first_indexed | 2024-03-12T00:05:30Z |
| format | Article |
| id | doaj.art-b4ff5b229b724537af8bda8c4d8e4f5c |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-03-12T00:05:30Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-b4ff5b229b724537af8bda8c4d8e4f5c2023-09-17T04:57:56ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252023-09-018100283Allicin: A review of its important pharmacological activitiesVivek D. Savairam0Neha A. Patil1Shrikant R. Borate2Mahesh M. Ghaisas3Rajkumar V. Shete4Department of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune 412206, India; Corresponding author.Department of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune 412206, IndiaDepartment of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune 412206, IndiaDepartment of Pharmacology, BVDU's Poona College of Pharmacy, Pune 411038, IndiaDepartment of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune 412206, India; Co-corresponding author: Rajgad Dnyanpeeth's College of Pharmacy, Pune, 412206, India.Background: Garlic (Allium sativum L.) is known for its synthesis of allicin, a defense molecule that exhibits various biological activities. Traditional medicine has utilized garlic to alleviate multiple ailments due to its broad spectrum of effects. Objective: This study aimed to review the ethnomedicinal potentials and pharmacological activities of allicin, the active constituent of garlic. Method: A comprehensive review was conducted to analyze in vitro and in vivo studies on allicin. The focus was on investigating its diverse pharmacological properties, including neuroprotection, anti-alzheimer, anti-inflammatory, anticancer, antioxidant, cardio protective, antidiabetic, and hepatoprotection activity. Results: The review revealed that allicin possesses a range of pharmacological activities. It showed neuroprotective effects, exhibited anti-inflammatory properties, demonstrated anticancer activity, acted as an antioxidant, provided cardioprotection, exerted antidiabetic effects, and offered hepatoprotection. Conclusion: The findings of this study suggest that allicin holds great potential for pharmaceutical industries in developing therapeutic products. However, to ensure the safe and effective use of allicin for treating various diseases, further research is necessary. Human clinical trials and quality control studies are essential to establish appropriate doses for pharmaceutical applications.http://www.sciencedirect.com/science/article/pii/S2667142523000696AllicinGarlicAllium sativumDiallyl thiosulfinateNeuroprotectiveCardiovascular diseases |
| spellingShingle | Vivek D. Savairam Neha A. Patil Shrikant R. Borate Mahesh M. Ghaisas Rajkumar V. Shete Allicin: A review of its important pharmacological activities Pharmacological Research - Modern Chinese Medicine Allicin Garlic Allium sativum Diallyl thiosulfinate Neuroprotective Cardiovascular diseases |
| title | Allicin: A review of its important pharmacological activities |
| title_full | Allicin: A review of its important pharmacological activities |
| title_fullStr | Allicin: A review of its important pharmacological activities |
| title_full_unstemmed | Allicin: A review of its important pharmacological activities |
| title_short | Allicin: A review of its important pharmacological activities |
| title_sort | allicin a review of its important pharmacological activities |
| topic | Allicin Garlic Allium sativum Diallyl thiosulfinate Neuroprotective Cardiovascular diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2667142523000696 |
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