Aetiology, Diagnosis and Clinical Characteristics of Nephrocalcinosis
Introduction: Nephrocalcinosis (NC) is the increased deposition of calcium in the renal parenchyma due to different aetiologies. Aim: The present study aimed to investigate the aetiology of NC and its effect on renal function and growth in children. Materials and Methods: In the present study, 25 ch...
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JCDR Research and Publications Private Limited
2018-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/11317/32270_F(SHU)_PF1(EK_SL)_PFA(EK_SL)_PB(EK_SL)_PN(AP).pdf |
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| author | Lidvana Spahiu Arbnore Batalli Këpuska Vlora Ismaili Jaha Besart MerovcI Haki Jashari |
| author_facet | Lidvana Spahiu Arbnore Batalli Këpuska Vlora Ismaili Jaha Besart MerovcI Haki Jashari |
| author_sort | Lidvana Spahiu |
| collection | DOAJ |
| description | Introduction: Nephrocalcinosis (NC) is the increased deposition of calcium in the renal parenchyma due to different aetiologies. Aim: The present study aimed to investigate the aetiology of NC and its effect on renal function and growth in children. Materials and Methods: In the present study, 25 children diagnosed with NC between 1999 and 2016 were retrospectively analysed. Relevant demographic, clinical and laboratory data were extracted from patients’ records. Results: The median (range) age at diagnosis was 9 (3-84) months. The leading cause of NC was distal Renal Tubular Acidosis (dRTA) in 16 (64%), followed by Idiopathic Hypercalciuria (IH) in 2 (8%) children. Clinical manifestations were failure to thrive in 8 (32%), polyuria and polydipsia in 5 (20%), haematuria and renal colic in 2 (8%), urinary tract infection in 7 (28%) and in 3 (12%) cases, NC was found accidentally during routine checkup. Chronic renal insufficiency developed in two patients with dRTA and in one with hyperoxaluria. The degree of NC worsened in 3 (23%) patients, remained the same in 7 (54%) and improved in 3 (23%) patients. However, the effect of nephrocalcinosis grade change on renal function and growth was not significant. Conclusion: It is not the degree of NC rather the underlying cause and the age at diagnosis that affects the growth and renal function of children. |
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| id | doaj.art-b500be4e4c8f49d2b1ac6b03ec43acfd |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-20T04:01:22Z |
| publishDate | 2018-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-b500be4e4c8f49d2b1ac6b03ec43acfd2022-12-21T19:54:09ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-03-01123SC09SC1210.7860/JCDR/2018/32270.11317Aetiology, Diagnosis and Clinical Characteristics of NephrocalcinosisLidvana Spahiu0Arbnore Batalli Këpuska1Vlora Ismaili Jaha2Besart MerovcI3Haki Jashari4Associate Professor, Department of Paediatric Nephrology, Paediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo.Lecturer, Department of Paediatric Nephrology, Paediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo.Lecturer, Department of Paediatric Nephrology, Paediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo.PhD Candidate, Department of Paediatric Nephrology, Paediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo.Lecturer, Department of Paediatric Nephrology, Paediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo.Introduction: Nephrocalcinosis (NC) is the increased deposition of calcium in the renal parenchyma due to different aetiologies. Aim: The present study aimed to investigate the aetiology of NC and its effect on renal function and growth in children. Materials and Methods: In the present study, 25 children diagnosed with NC between 1999 and 2016 were retrospectively analysed. Relevant demographic, clinical and laboratory data were extracted from patients’ records. Results: The median (range) age at diagnosis was 9 (3-84) months. The leading cause of NC was distal Renal Tubular Acidosis (dRTA) in 16 (64%), followed by Idiopathic Hypercalciuria (IH) in 2 (8%) children. Clinical manifestations were failure to thrive in 8 (32%), polyuria and polydipsia in 5 (20%), haematuria and renal colic in 2 (8%), urinary tract infection in 7 (28%) and in 3 (12%) cases, NC was found accidentally during routine checkup. Chronic renal insufficiency developed in two patients with dRTA and in one with hyperoxaluria. The degree of NC worsened in 3 (23%) patients, remained the same in 7 (54%) and improved in 3 (23%) patients. However, the effect of nephrocalcinosis grade change on renal function and growth was not significant. Conclusion: It is not the degree of NC rather the underlying cause and the age at diagnosis that affects the growth and renal function of children.https://jcdr.net/articles/PDF/11317/32270_F(SHU)_PF1(EK_SL)_PFA(EK_SL)_PB(EK_SL)_PN(AP).pdfdistal renal tubular acidosisgrowth failurerenal function |
| spellingShingle | Lidvana Spahiu Arbnore Batalli Këpuska Vlora Ismaili Jaha Besart MerovcI Haki Jashari Aetiology, Diagnosis and Clinical Characteristics of Nephrocalcinosis Journal of Clinical and Diagnostic Research distal renal tubular acidosis growth failure renal function |
| title | Aetiology, Diagnosis and Clinical Characteristics of Nephrocalcinosis |
| title_full | Aetiology, Diagnosis and Clinical Characteristics of Nephrocalcinosis |
| title_fullStr | Aetiology, Diagnosis and Clinical Characteristics of Nephrocalcinosis |
| title_full_unstemmed | Aetiology, Diagnosis and Clinical Characteristics of Nephrocalcinosis |
| title_short | Aetiology, Diagnosis and Clinical Characteristics of Nephrocalcinosis |
| title_sort | aetiology diagnosis and clinical characteristics of nephrocalcinosis |
| topic | distal renal tubular acidosis growth failure renal function |
| url | https://jcdr.net/articles/PDF/11317/32270_F(SHU)_PF1(EK_SL)_PFA(EK_SL)_PB(EK_SL)_PN(AP).pdf |
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