Night blood pressure variability, brain atrophy, and cognitive decline
BackgroundAlthough blood pressure variability (BPV) has emerged as a novel risk factor for Alzheimer's disease, few studies have examined the effects of night BPV on brain structure and function. This study investigated the association of night BPV with brain atrophy and cognitive function chan...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.963648/full |
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| author | Ji Hee Yu Regina E. Y. Kim Regina E. Y. Kim So Young Park Da Young Lee Hyun Joo Cho Nam Hoon Kim Hye Jin Yoo Ji A Seo Seong Hwan Kim Sin Gon Kim Kyung Mook Choi Sei Hyun Baik Chol Shin Nan Hee Kim |
| author_facet | Ji Hee Yu Regina E. Y. Kim Regina E. Y. Kim So Young Park Da Young Lee Hyun Joo Cho Nam Hoon Kim Hye Jin Yoo Ji A Seo Seong Hwan Kim Sin Gon Kim Kyung Mook Choi Sei Hyun Baik Chol Shin Nan Hee Kim |
| author_sort | Ji Hee Yu |
| collection | DOAJ |
| description | BackgroundAlthough blood pressure variability (BPV) has emerged as a novel risk factor for Alzheimer's disease, few studies have examined the effects of night BPV on brain structure and function. This study investigated the association of night BPV with brain atrophy and cognitive function changes.MethodsThe analysis included 1,398 participants with valid ambulatory blood pressure (BP) monitoring at baseline and both baseline and 4-year follow-up brain magnetic resonance images who were recruited from the Korean Genome and Epidemiology Study. Participants underwent a comprehensive neuropsychological test battery. BPV was derived from ambulatory BP monitoring and calculated as a standard deviation (SD) of 24-h and daytime and nighttime BP.ResultsDuring the median follow-up of 4.3 years, increased SD of night systolic or diastolic BP was an indicator of total brain volume reduction, while daytime BPV or night average BP was not associated with total brain volume changes. High SD of night systolic BP was associated with reduced gray matter (GM) volume, independent of average night BP, and use of antihypertensive drugs. It also was associated with a reduction of temporal GM volume, mostly driven by atrophy in the left entorhinal cortex and the right fusiform gyrus. In cognitive performance, high variability of night systolic BP was associated with a decrease in visual delayed recall memory and verbal fluency for the category.ConclusionIncreased night BPV, rather than night mean BP, was associated with reduced brain volume and cognitive decline. High night BPV could be an independent predictor for rapid brain aging in a middle-aged population. |
| first_indexed | 2024-04-11T14:13:51Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T14:13:51Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-b504658f5956496cb7968eb5d4f056082022-12-22T04:19:36ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.963648963648Night blood pressure variability, brain atrophy, and cognitive declineJi Hee Yu0Regina E. Y. Kim1Regina E. Y. Kim2So Young Park3Da Young Lee4Hyun Joo Cho5Nam Hoon Kim6Hye Jin Yoo7Ji A Seo8Seong Hwan Kim9Sin Gon Kim10Kyung Mook Choi11Sei Hyun Baik12Chol Shin13Nan Hee Kim14Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaInstitute of Human Genomic Study, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South KoreaDepartment of Psychiatry, University of Iowa, Iowa City, IA, United StatesDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaInstitute of Human Genomic Study, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South KoreaBackgroundAlthough blood pressure variability (BPV) has emerged as a novel risk factor for Alzheimer's disease, few studies have examined the effects of night BPV on brain structure and function. This study investigated the association of night BPV with brain atrophy and cognitive function changes.MethodsThe analysis included 1,398 participants with valid ambulatory blood pressure (BP) monitoring at baseline and both baseline and 4-year follow-up brain magnetic resonance images who were recruited from the Korean Genome and Epidemiology Study. Participants underwent a comprehensive neuropsychological test battery. BPV was derived from ambulatory BP monitoring and calculated as a standard deviation (SD) of 24-h and daytime and nighttime BP.ResultsDuring the median follow-up of 4.3 years, increased SD of night systolic or diastolic BP was an indicator of total brain volume reduction, while daytime BPV or night average BP was not associated with total brain volume changes. High SD of night systolic BP was associated with reduced gray matter (GM) volume, independent of average night BP, and use of antihypertensive drugs. It also was associated with a reduction of temporal GM volume, mostly driven by atrophy in the left entorhinal cortex and the right fusiform gyrus. In cognitive performance, high variability of night systolic BP was associated with a decrease in visual delayed recall memory and verbal fluency for the category.ConclusionIncreased night BPV, rather than night mean BP, was associated with reduced brain volume and cognitive decline. High night BPV could be an independent predictor for rapid brain aging in a middle-aged population.https://www.frontiersin.org/articles/10.3389/fneur.2022.963648/fullnight blood pressurevariabilitygray matterbrain atrophycognition |
| spellingShingle | Ji Hee Yu Regina E. Y. Kim Regina E. Y. Kim So Young Park Da Young Lee Hyun Joo Cho Nam Hoon Kim Hye Jin Yoo Ji A Seo Seong Hwan Kim Sin Gon Kim Kyung Mook Choi Sei Hyun Baik Chol Shin Nan Hee Kim Night blood pressure variability, brain atrophy, and cognitive decline Frontiers in Neurology night blood pressure variability gray matter brain atrophy cognition |
| title | Night blood pressure variability, brain atrophy, and cognitive decline |
| title_full | Night blood pressure variability, brain atrophy, and cognitive decline |
| title_fullStr | Night blood pressure variability, brain atrophy, and cognitive decline |
| title_full_unstemmed | Night blood pressure variability, brain atrophy, and cognitive decline |
| title_short | Night blood pressure variability, brain atrophy, and cognitive decline |
| title_sort | night blood pressure variability brain atrophy and cognitive decline |
| topic | night blood pressure variability gray matter brain atrophy cognition |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.963648/full |
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