A Meta-Analysis of the Association between ESR1 Genetic Variants and the Risk of Breast Cancer.
BACKGROUND:Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene (ESR1) play critical roles in breast cancer (BC) susceptibility. Genome-wide association studies have reported that SNPs in ESR1 are associated with BC susceptibility; however, the results of recent studies have been inc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4829239?pdf=render |
| _version_ | 1818357502129995776 |
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| author | Taishun Li Jun Zhao Jiaying Yang Xu Ma Qiaoyun Dai Hao Huang Lina Wang Pei Liu |
| author_facet | Taishun Li Jun Zhao Jiaying Yang Xu Ma Qiaoyun Dai Hao Huang Lina Wang Pei Liu |
| author_sort | Taishun Li |
| collection | DOAJ |
| description | BACKGROUND:Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene (ESR1) play critical roles in breast cancer (BC) susceptibility. Genome-wide association studies have reported that SNPs in ESR1 are associated with BC susceptibility; however, the results of recent studies have been inconsistent. Therefore, we performed this meta-analysis to obtain more accurate and credible results. METHODS:We pooled published literature from PubMed, EMBASE, and Web of Science and calculated odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of associations using fixed effects models and random effects models. Twenty relevant case-control and cohort studies of the 3 related SNPs were identified. RESULTS:Three SNPs of the ESR1 gene, rs2077647:T>C, rs2228480:G>A and rs3798577:T>C, were not associated with increased BC risk in our overall meta-analysis. Stratified analysis by ethnicity showed that in Caucasians, the rs2228480 AA genotype was associated with a 26% decreased risk of BC compared with the GG genotype (OR = 0.740, 95% CI: 0.555-0.987). The C allele of the rs3798577:T>C variant was associated with decreased BC risk in Asians (OR = 0.828, 95% CI: 0.730-0.939), while Caucasians with this allele were found to experience significantly increased BC risk (OR = 1.551, 95% CI: 1.037-2.321). A non-significant association between rs2077647 and BC risk was identified in all of the evaluated ethnic populations. CONCLUSION:Rs3798577 was associated with an increased risk of BC in Caucasian populations but a decreased risk in Asians. Rs2228480 had a large protective effect in Caucasians, while rs2077647 was not associated with BC risk. |
| first_indexed | 2024-12-13T20:14:07Z |
| format | Article |
| id | doaj.art-b5071cf08e1c4332a00426cbdc8e408c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T20:14:07Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b5071cf08e1c4332a00426cbdc8e408c2022-12-21T23:32:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015331410.1371/journal.pone.0153314A Meta-Analysis of the Association between ESR1 Genetic Variants and the Risk of Breast Cancer.Taishun LiJun ZhaoJiaying YangXu MaQiaoyun DaiHao HuangLina WangPei LiuBACKGROUND:Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene (ESR1) play critical roles in breast cancer (BC) susceptibility. Genome-wide association studies have reported that SNPs in ESR1 are associated with BC susceptibility; however, the results of recent studies have been inconsistent. Therefore, we performed this meta-analysis to obtain more accurate and credible results. METHODS:We pooled published literature from PubMed, EMBASE, and Web of Science and calculated odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of associations using fixed effects models and random effects models. Twenty relevant case-control and cohort studies of the 3 related SNPs were identified. RESULTS:Three SNPs of the ESR1 gene, rs2077647:T>C, rs2228480:G>A and rs3798577:T>C, were not associated with increased BC risk in our overall meta-analysis. Stratified analysis by ethnicity showed that in Caucasians, the rs2228480 AA genotype was associated with a 26% decreased risk of BC compared with the GG genotype (OR = 0.740, 95% CI: 0.555-0.987). The C allele of the rs3798577:T>C variant was associated with decreased BC risk in Asians (OR = 0.828, 95% CI: 0.730-0.939), while Caucasians with this allele were found to experience significantly increased BC risk (OR = 1.551, 95% CI: 1.037-2.321). A non-significant association between rs2077647 and BC risk was identified in all of the evaluated ethnic populations. CONCLUSION:Rs3798577 was associated with an increased risk of BC in Caucasian populations but a decreased risk in Asians. Rs2228480 had a large protective effect in Caucasians, while rs2077647 was not associated with BC risk.http://europepmc.org/articles/PMC4829239?pdf=render |
| spellingShingle | Taishun Li Jun Zhao Jiaying Yang Xu Ma Qiaoyun Dai Hao Huang Lina Wang Pei Liu A Meta-Analysis of the Association between ESR1 Genetic Variants and the Risk of Breast Cancer. PLoS ONE |
| title | A Meta-Analysis of the Association between ESR1 Genetic Variants and the Risk of Breast Cancer. |
| title_full | A Meta-Analysis of the Association between ESR1 Genetic Variants and the Risk of Breast Cancer. |
| title_fullStr | A Meta-Analysis of the Association between ESR1 Genetic Variants and the Risk of Breast Cancer. |
| title_full_unstemmed | A Meta-Analysis of the Association between ESR1 Genetic Variants and the Risk of Breast Cancer. |
| title_short | A Meta-Analysis of the Association between ESR1 Genetic Variants and the Risk of Breast Cancer. |
| title_sort | meta analysis of the association between esr1 genetic variants and the risk of breast cancer |
| url | http://europepmc.org/articles/PMC4829239?pdf=render |
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