H2O2-responsive VEGF/NGF gene co-delivery nano-system achieves stable vascularization in ischemic hindlimbs

H2O2-responsive VEGF/NGF gene co-delivery nano-system achieves stable vascularization in ischemic hindlimbs

Abstract Peripheral vascular disease (PVD) is a common clinical manifestation of atherosclerosis. Vascular endothelial growth factor (VEGF) gene therapy is a promising approach for PVD treatment. However, due to single-gene therapy limitations and high H2O2 pathological microenvironment, VEGF gene t...

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Bibliographic Details
Main Authors: Youlu Chen, Zuoguan Chen, Jianwei Duan, Liang Gui, Huiyang Li, Xiaoyu Liang, Xinxin Tian, Kaijing Liu, Yongjun Li, Jing Yang
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Nanobiotechnology
Subjects:
Vascular endothelial growth factor
Nerve growth factor
Gene therapy
Hydrogen peroxide
Angiogenesis
Online Access:https://doi.org/10.1186/s12951-022-01328-6

Internet

https://doi.org/10.1186/s12951-022-01328-6

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