Orbitofrontal cortex and the early processing of visual novelty in healthy aging
Event-related potential (ERP) studies have previously found that scalp topographies of attention-related ERP components show frontal shifts with age, suggesting an increased need for compensatory frontal activity to assist with top-down facilitation of attention. However, the precise neural time co...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-05-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00101/full |
| _version_ | 1818556980180025344 |
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| author | David A S Kaufman Cierra M. Keith William M. Perlstein |
| author_facet | David A S Kaufman Cierra M. Keith William M. Perlstein |
| author_sort | David A S Kaufman |
| collection | DOAJ |
| description | Event-related potential (ERP) studies have previously found that scalp topographies of attention-related ERP components show frontal shifts with age, suggesting an increased need for compensatory frontal activity to assist with top-down facilitation of attention. However, the precise neural time course of top-down attentional control in aging is not clear. In this study, 20 young (mean: 22 years) and 14 older (mean: 64 years) adults completed a three-stimulus visual oddball task while high-density ERPs were acquired. Colorful, novel distracters were presented to engage early visual processing. Relative to young controls, older participants exhibited elevations in occipital early posterior positivity (EPP), approximately 100 ms after viewing colorful distracters. Neural source models for older adults implicated unique patterns of orbitofrontal cortex (BA 11) activity during early visual novelty processing (100 ms), which was positively correlated with subsequent activations in primary visual cortex (BA 17). Older adult EPP amplitudes and OFC activity were associated with performance on tests of complex attention and executive function. These findings are suggestive of age-related, compensatory neural changes that may driven by a combination of weaker cortical efficiency and increased need for top-down control over attention. Accordingly, enhanced early OFC activity during visual attention may serve as an important indicator of frontal lobe integrity in healthy aging. |
| first_indexed | 2024-12-13T23:54:11Z |
| format | Article |
| id | doaj.art-b509d787395b4e9484551d7394842f32 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-13T23:54:11Z |
| publishDate | 2016-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-b509d787395b4e9484551d7394842f322022-12-21T23:26:41ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-05-01810.3389/fnagi.2016.00101179957Orbitofrontal cortex and the early processing of visual novelty in healthy agingDavid A S Kaufman0Cierra M. Keith1William M. Perlstein2Saint Louis UniversitySaint Louis UniversityUniversity of FloridaEvent-related potential (ERP) studies have previously found that scalp topographies of attention-related ERP components show frontal shifts with age, suggesting an increased need for compensatory frontal activity to assist with top-down facilitation of attention. However, the precise neural time course of top-down attentional control in aging is not clear. In this study, 20 young (mean: 22 years) and 14 older (mean: 64 years) adults completed a three-stimulus visual oddball task while high-density ERPs were acquired. Colorful, novel distracters were presented to engage early visual processing. Relative to young controls, older participants exhibited elevations in occipital early posterior positivity (EPP), approximately 100 ms after viewing colorful distracters. Neural source models for older adults implicated unique patterns of orbitofrontal cortex (BA 11) activity during early visual novelty processing (100 ms), which was positively correlated with subsequent activations in primary visual cortex (BA 17). Older adult EPP amplitudes and OFC activity were associated with performance on tests of complex attention and executive function. These findings are suggestive of age-related, compensatory neural changes that may driven by a combination of weaker cortical efficiency and increased need for top-down control over attention. Accordingly, enhanced early OFC activity during visual attention may serve as an important indicator of frontal lobe integrity in healthy aging.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00101/fullAgingAttentionorbitofrontal cortexERPsoddballsLORETA source localization |
| spellingShingle | David A S Kaufman Cierra M. Keith William M. Perlstein Orbitofrontal cortex and the early processing of visual novelty in healthy aging Frontiers in Aging Neuroscience Aging Attention orbitofrontal cortex ERPs oddball sLORETA source localization |
| title | Orbitofrontal cortex and the early processing of visual novelty in healthy aging |
| title_full | Orbitofrontal cortex and the early processing of visual novelty in healthy aging |
| title_fullStr | Orbitofrontal cortex and the early processing of visual novelty in healthy aging |
| title_full_unstemmed | Orbitofrontal cortex and the early processing of visual novelty in healthy aging |
| title_short | Orbitofrontal cortex and the early processing of visual novelty in healthy aging |
| title_sort | orbitofrontal cortex and the early processing of visual novelty in healthy aging |
| topic | Aging Attention orbitofrontal cortex ERPs oddball sLORETA source localization |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00101/full |
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