The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview
Abstract Introduction Cardiac arrhythmias, including ventricular tachycardia (VT), stand as a significant threat to health, often leading to mortality and sudden cardiac death. While conventional treatments for VT exhibit efficacy, cases of refractory VT pose challenges. Stereotactic Arrhythmia Radi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.1741 |
| _version_ | 1797375200722944000 |
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| author | Farzad MasoudKabir Reyhaneh Bayani Nima Mousavi Darzikolaee Alireza Abdshah Mahsa Moshtaghian Farshid Farhan Mahdi Aghili Ali Kazemian Luca Nicosia Francesco Cuccia Ana Vitoria Rocha Fatemeh Jafari Filippo Alongi |
| author_facet | Farzad MasoudKabir Reyhaneh Bayani Nima Mousavi Darzikolaee Alireza Abdshah Mahsa Moshtaghian Farshid Farhan Mahdi Aghili Ali Kazemian Luca Nicosia Francesco Cuccia Ana Vitoria Rocha Fatemeh Jafari Filippo Alongi |
| author_sort | Farzad MasoudKabir |
| collection | DOAJ |
| description | Abstract Introduction Cardiac arrhythmias, including ventricular tachycardia (VT), stand as a significant threat to health, often leading to mortality and sudden cardiac death. While conventional treatments for VT exhibit efficacy, cases of refractory VT pose challenges. Stereotactic Arrhythmia Radioablation (STAR) offers a novel approach, delivering precise high‐dose radiation to well‐defined targets with minimal collateral damage. This study explores the potential of STAR as an alternative therapy, especially for high‐risk patients or those with refractory VT. Methods This research reviews ongoing studies and preliminary investigations into the evaluation of the efficacy and safety of STAR. The method involves targeted radiation delivery, assessing reductions in VT recurrence and the early safety profile in refractory VT patients. However, given STAR's early stage and limited clinical evidence, cautious interpretation is advised. Results Preliminary findings indicate a reduction in VT recurrence with STAR, suggesting promise as a therapeutic option. Early safety profiles are encouraging, but definitive statements on efficacy and safety require further investigation. Positive initial outcomes underscore the need for additional data and long‐term studies. Conclusion Stereotactic Arrhythmia Radioablation is recently emerging as a promising treatment for refractory VT. While early results are encouraging, careful interpretation is needed, due to STAR's early stages. Ongoing investigations are critical for a comprehensive understanding of its long‐term efficacy and tolerability. This review provides fundamental insights into STAR's background, principles, pre‐treatment procedures, clinical implications, and toxicity, setting the stage for future research in this evolving therapeutic field. |
| first_indexed | 2024-03-08T19:18:50Z |
| format | Article |
| id | doaj.art-b50c334542fb413697f3fe1cf5029a89 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-08T19:18:50Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-b50c334542fb413697f3fe1cf5029a892023-12-27T00:48:32ZengWileyHealth Science Reports2398-88352023-12-01612n/an/a10.1002/hsr2.1741The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overviewFarzad MasoudKabir0Reyhaneh Bayani1Nima Mousavi Darzikolaee2Alireza Abdshah3Mahsa Moshtaghian4Farshid Farhan5Mahdi Aghili6Ali Kazemian7Luca Nicosia8Francesco Cuccia9Ana Vitoria Rocha10Fatemeh Jafari11Filippo Alongi12Cardiac Primary Prevention Research Center Tehran University of Medical Sciences Tehran IranDepartment of Radiation Oncology Hamadan University of Medical Sciences Hamadan IranRadiation Oncology Research Center (RORC) Tehran University of Medical Sciences Tehran IranSchool of Medicine Tehran University of Medical Sciences Tehran IranCancer Research Center, Cancer institute of Iran, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran IranCancer Research Center, Cancer institute of Iran, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran IranCancer Research Center, Cancer institute of Iran, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran IranDepartment of Radiation Oncology, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran IranAdvanced Radiation Oncology Department IRCCS Ospedale Sacro Cuore Don Calabria Negrar‐Verona ItalyAdvanced Radiation Oncology Department IRCCS Ospedale Sacro Cuore Don Calabria Negrar‐Verona ItalyDivision of Medicine Federal University of Goias Goiânia BrazilCancer Research Center, Cancer institute of Iran, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran IranAdvanced Radiation Oncology Department IRCCS Ospedale Sacro Cuore Don Calabria Negrar‐Verona ItalyAbstract Introduction Cardiac arrhythmias, including ventricular tachycardia (VT), stand as a significant threat to health, often leading to mortality and sudden cardiac death. While conventional treatments for VT exhibit efficacy, cases of refractory VT pose challenges. Stereotactic Arrhythmia Radioablation (STAR) offers a novel approach, delivering precise high‐dose radiation to well‐defined targets with minimal collateral damage. This study explores the potential of STAR as an alternative therapy, especially for high‐risk patients or those with refractory VT. Methods This research reviews ongoing studies and preliminary investigations into the evaluation of the efficacy and safety of STAR. The method involves targeted radiation delivery, assessing reductions in VT recurrence and the early safety profile in refractory VT patients. However, given STAR's early stage and limited clinical evidence, cautious interpretation is advised. Results Preliminary findings indicate a reduction in VT recurrence with STAR, suggesting promise as a therapeutic option. Early safety profiles are encouraging, but definitive statements on efficacy and safety require further investigation. Positive initial outcomes underscore the need for additional data and long‐term studies. Conclusion Stereotactic Arrhythmia Radioablation is recently emerging as a promising treatment for refractory VT. While early results are encouraging, careful interpretation is needed, due to STAR's early stages. Ongoing investigations are critical for a comprehensive understanding of its long‐term efficacy and tolerability. This review provides fundamental insights into STAR's background, principles, pre‐treatment procedures, clinical implications, and toxicity, setting the stage for future research in this evolving therapeutic field.https://doi.org/10.1002/hsr2.1741arrhythmiaatrial fibrillationradiation therapyradioablationventricular tachycardia |
| spellingShingle | Farzad MasoudKabir Reyhaneh Bayani Nima Mousavi Darzikolaee Alireza Abdshah Mahsa Moshtaghian Farshid Farhan Mahdi Aghili Ali Kazemian Luca Nicosia Francesco Cuccia Ana Vitoria Rocha Fatemeh Jafari Filippo Alongi The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview Health Science Reports arrhythmia atrial fibrillation radiation therapy radioablation ventricular tachycardia |
| title | The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview |
| title_full | The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview |
| title_fullStr | The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview |
| title_full_unstemmed | The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview |
| title_short | The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview |
| title_sort | state of the art technic of stereotactic radioablation for the treatment of cardiac arrhythmias an overview |
| topic | arrhythmia atrial fibrillation radiation therapy radioablation ventricular tachycardia |
| url | https://doi.org/10.1002/hsr2.1741 |
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