Factors influencing recovery in patients with hemoblastoses and candidemia
Aim. To study the factors influencing the results of treatment for candidemia (CE) in patients with blood system tumors. Subjects and methods. The investigation enrolled patients with hemoblastoses and CE. 30-day all-cause mortality was analyzed. Results. In an 8-year period (2006—2013), CE was diag...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2015-07-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31787 |
| _version_ | 1811208943062482944 |
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| author | G A Klyasova E V Blokhina A N Gracheva S K Kravchenko E N Parovichnikova V A Okhmat A G Korobova G M Galstyan S M Kulikov |
| author_facet | G A Klyasova E V Blokhina A N Gracheva S K Kravchenko E N Parovichnikova V A Okhmat A G Korobova G M Galstyan S M Kulikov |
| author_sort | G A Klyasova |
| collection | DOAJ |
| description | Aim. To study the factors influencing the results of treatment for candidemia (CE) in patients with blood system tumors. Subjects and methods. The investigation enrolled patients with hemoblastoses and CE. 30-day all-cause mortality was analyzed. Results. In an 8-year period (2006—2013), CE was diagnosed in 55 patients (median age, 50 years); there was a preponderance of patients with lymphomas (47%) and acute leukemias (27%). The causative agents of CE were C. albicans (38%), С. parapsilosis (17%), С. krusei (11%), C. guilliermondii (11%), C. lusitaniae (6%), C. tropicalis (6%), С. glabrata (3%), С. famata (3%), C. pelliculosa (3%), and C. kefyr (2%). 30-day all-cause mortality was 43.6%. Recovery was statistically significantly more frequently seen following removal of a central venous catheter (67% versus 13%; p=0.004; odds ratio (OR), 14); after use of an antifungal drug on day 1 of isolation of Candida spp. from blood cultures (62% versus 13%; p=0.01; OR, 12); and that of echocandin as a first-line agent (86% versus 42%; p=0.005; OR, 8.4). The poor predictors were septic shock (5% recovery rate versus 86% in the patients without this factor; p |
| first_indexed | 2024-04-12T04:31:34Z |
| format | Article |
| id | doaj.art-b50cf275466444e5a126a15ad1fac95e |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T04:31:34Z |
| publishDate | 2015-07-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-b50cf275466444e5a126a15ad1fac95e2022-12-22T03:47:56Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422015-07-01877778728803Factors influencing recovery in patients with hemoblastoses and candidemiaG A KlyasovaE V BlokhinaA N GrachevaS K KravchenkoE N ParovichnikovaV A OkhmatA G KorobovaG M GalstyanS M KulikovAim. To study the factors influencing the results of treatment for candidemia (CE) in patients with blood system tumors. Subjects and methods. The investigation enrolled patients with hemoblastoses and CE. 30-day all-cause mortality was analyzed. Results. In an 8-year period (2006—2013), CE was diagnosed in 55 patients (median age, 50 years); there was a preponderance of patients with lymphomas (47%) and acute leukemias (27%). The causative agents of CE were C. albicans (38%), С. parapsilosis (17%), С. krusei (11%), C. guilliermondii (11%), C. lusitaniae (6%), C. tropicalis (6%), С. glabrata (3%), С. famata (3%), C. pelliculosa (3%), and C. kefyr (2%). 30-day all-cause mortality was 43.6%. Recovery was statistically significantly more frequently seen following removal of a central venous catheter (67% versus 13%; p=0.004; odds ratio (OR), 14); after use of an antifungal drug on day 1 of isolation of Candida spp. from blood cultures (62% versus 13%; p=0.01; OR, 12); and that of echocandin as a first-line agent (86% versus 42%; p=0.005; OR, 8.4). The poor predictors were septic shock (5% recovery rate versus 86% in the patients without this factor; phttps://ter-arkhiv.ru/0040-3660/article/view/31787candidemia treatmentechinocandinsamphotericin bhemoblastoses |
| spellingShingle | G A Klyasova E V Blokhina A N Gracheva S K Kravchenko E N Parovichnikova V A Okhmat A G Korobova G M Galstyan S M Kulikov Factors influencing recovery in patients with hemoblastoses and candidemia Терапевтический архив candidemia treatment echinocandins amphotericin b hemoblastoses |
| title | Factors influencing recovery in patients with hemoblastoses and candidemia |
| title_full | Factors influencing recovery in patients with hemoblastoses and candidemia |
| title_fullStr | Factors influencing recovery in patients with hemoblastoses and candidemia |
| title_full_unstemmed | Factors influencing recovery in patients with hemoblastoses and candidemia |
| title_short | Factors influencing recovery in patients with hemoblastoses and candidemia |
| title_sort | factors influencing recovery in patients with hemoblastoses and candidemia |
| topic | candidemia treatment echinocandins amphotericin b hemoblastoses |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31787 |
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