Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice

Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice

Familial hemiplegic migraine type 1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in CaV2.1 (P/Q-type) calcium channels. In FHM1 knockin mice, excitatory neurotransmission at cortical pyramidal cell synapses is enhanced, but inhibitory neurotransmission a...

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Bibliographic Details
Main Authors: Dania Vecchia, Angelita Tottene, Arn M.J.M. van den Maagdenberg, Daniela Pietrobon
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Neurobiology of Disease
Subjects:
Migraine
Fast-spiking interneuron
Knockin mouse model
Channelopathy
Excitatory–inhibitory balance
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001533

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